| | This subclass is indented under Class 260, subclass
1. Compounds consisting of three or more amino acids joined
covalently by peptide bonds.
| | (1)
Note. A peptide bond is an amino bond between the carboxyl
group of one amino acid and the amino group of another. |
| | (2)
Note. The border line, for purposes of subclasses 300 to
427, between peptides and proteins has been drawn at 100 amino acid
residues or a molecular weight of about 10,000 where the number
of residues is unknown. |
| | (3)
Note. Related peptides. A peptide is classifiable in a given
subclass if its structure corresponds to at least half the amino
acid residues of the named peptide. The product of side chain substitution,
C or N terminal chain will be classified with the named peptide
as related peptides. The product of a replacement reaction will
be classified as a related peptide so long as less than half the
amino acid residues of the named peptide have been replaced. The
product of a removal reaction or a partial sequence (i.e., fragments)
will be classifed as a related peptide if half the amino acid residues
of the named peptide are present. Polypeptides which are formed
by joining the named peptide of identical sequence to the named
peptide should be originally classified on the basis of the named
peptide and cross-referenced to the appropriate subclasses. |
| | (4)
Note. Functional Analogues. Peptides claimed or disclosed
as a functional analogue should be classified on the basis of structure,
i.e., is the structure of the analogue a related peptide, and cross-referenced
to the subclass providing for the named peptide that the patented
peptide is claimed or disclosed as functioning like. If there is
no structural information present in the patent or otherwise obtainable
on the structural analogue, the patent should be originally classified
in the generic peptide subclass and cross-referenced to the subclass
providing for the named peptides. |
| | (5)
Note. Joined peptide subunits. In the case where peptide
chains are joined by covalent bonding as by S-S bonds through cysteine
the number of amino acids in the peptide is the sum of the individual
chains. |
| | (6)
Note. IUPAC-IUB Nonmenclature. Published in Archives of
Biochemistry and Biophysics. Titles: (1) Abbreviations and Symbols
for chemical Names of Special Interest in Biological Chemistry;
Revised Tentative Rules (1965); Section 5, Nucleic Acids and Nucleotides,
year (1966), Volume 115, pages 1-12. (2) Abbreviated Designation
of Amino Acid Derivatives and Peptides, year (1967), Volume 123,
pages 1-5. (3) Rules for Naming Synthetic Modifications of Natural
Peptides, year (1966), Volume 121, pages 6-8. (4) Abbreviated Nonmenclature
of Synthetic Polypeptides (polymerized Amino Acid), year (1968),
Volume 123, pages 633-637. (5) A One-Letter Notation for Amino Acids, year
(1968), Volume 125, pages 1-5. (6) Abbreviations and Symbols for
the Description of the Conformation of Polypeptides Chains; Tentative
Rules (1969), year (1971), Volume 145, pages 405-421. |
| | (7)
Note. CAS REGISTRY NUMBERS Chemical Abstract Service (CAS)
Registry Numbers are unique identifiers assigned to chemical substances recorded
in the CAS Chemical Registry System. The CAS Registry Number itself
has no chemical significance; it is simply a machine-checkable number assigned
to each substance as it enters the Registry System. CAS Registry Numbers
appear in CA issues and in many computer-readable files. They also
may be found in several primary journals, various handbooks, and
in the National Library handbooks, and in the National Library of
Medicine"s TOXLINE and CHEMLINE computer-based information-retrieval
services. For more about the CAS Chemical Registry System or Registry
System or Registry Numbers consult the introduction to the CAS REGISTRY
HANDBOOK-Number Section.
| |
Medical Subject Headings: (1) Mesh Tree Numbers: Mesh numbers
are identifiers applied to the National Library of Medicine"s
indexers to articles in the medical and related literature. The
subject headings are Index Medicus headings and are arranged in
a hierarchical matter. The abstracts and indexing are available
on line through several data base suppliers. (2) Deleted Registry Numbers:
The CA registry numbers found in the definitions of subclass 300 to
427 are the current registry numbers. However, due to the long
history and incomplete structural knowledge of peptide and protein
chemistry, there are usually several deleted registry numbers for each
current registry number. The current registry number should be
used to find the deleted numbers in the registry file and should
always be included in the online search statement. For further information
on search technique related to deleted registry numbers see, CAS ONLINE
NEWS May/June 1984, page 5. | |
| | (8)
Note. Structure. The primary structure of the shorter peptide
has been included in the definitions. For the larger peptides the
Merck Monograph will often provide citations to articles disclosing
the structure. The structure of the larger peptides and proteins
may be found on the on-line services by using the compound name, C10hemical
Abstracts Registry Number, or National Library of Medicine"s MESH
tree number in combination with the terms "sequence" or "structure". |
| | (9)
Note. Compositions. In general a peptide or protein containing
composition will be provided for in a class providing for the function
or utility of the composition, e.g., medicine, food, Class 252, utilities,
etc. A peptide mixed with a preserving agent whose sole function
is to prevent chemical or physical change is provided for with the
peptide or protein. A peptide derived from a single source material
such as a plant or animal extract, so long as it is identified as
a protein or peptide, is classified in this class (530) even if
a Class 424 utility is disclosed or claimed. A plant or animal extract will be provided in Class 424 if it is
(a) a single source material and (b) is of undetermined chemical
constitution, i.e., is claimed in terms of isolation technique or
physical properties. A recitation as broad as "peptide" is
enough to defeat placement in Class 424 on the basis of utility.
Class 424 will provide for an additive mixture containing a peptide
and other ingredients if the mixture has a Class 424 utility. |
| | (10)
Note. Classification of the more common amino acids:
| | Amino Acids | | |
Classification |
| | Amino Acids commonly found in peptides and proteins: | | |
|
| | Alanine | | |
562/575 |
| | Arginine | | |
562/560 |
| | Asparagine | | |
562/561 |
| | Aspartic acid | | |
562/571 |
| | Cysteine | | |
562/557 |
| | Glutamine | | |
562/563 |
| | Glutamic acid | | |
562/573 |
| | Glycine | | |
562/575 |
| | Histidine | | |
548/344 |
| | Isoleucine | | |
562/575 |
| | Leucine | | |
562/575 |
| | Lysine | | |
562/562 |
| | Methionine | | |
562/559 |
| | Phenylalanine | | |
562/445 |
| | Proline | | |
548/535 |
| | Serine | | |
562/567 |
| | Threonine | | |
562/570 |
| | Tryptophan | | |
548/496 |
| | Tyrosine | | |
562/444 |
| | Rare amino acids from protein | | |
|
| | Desmosine | | |
546/335 |
| | 5 Hydroxylsine | | |
562/564 |
| | 5 Hydroxyproline | | |
548/532 |
| | Isodesmosine | | |
546/335 |
| | 3-Methylthistidine | | |
548/335 |
| | E-N-Methyllysine | | |
562/561 |
| | Nonprotein Amino Acids | | |
|
| | B-Alanine | | |
562/567 |
| | V-Aminobutyric Acid | | |
562/553 |
| | Canavanine | | |
562/560 |
| | Citrulline | | |
562/560 |
| | B-Cyanvalanine | | |
260/465 |
| | Djenkolic acid | | |
562/557 |
| | Homocysteine | | |
562/556 |
| | Homoserine | | |
562/567 |
| | Ornithine | | |
562/561 |
| | Valine | | |
526/575 | |
| | (11)
Note. Synthetic Resins vs. Polypeptides. The conceptual
difference between the subject matter of synthetic resins provided
for in the 520 series and polypeptides (including proteins) provided
for in Class 530 is that the compounds of the 520 series have statistically
distributed amino acids or blocks of amino acids in their molecules in
a random sequence whereas 530 provides for molecules composed of
a specific sequence of amino acids defined identity and order (i.e.,
primary structure) having identity or closed relation to a humorial
or cellular polypeptide or having some humorial or cellular effect due
to its ordered structure. |
| | (12)
Note. Peptide and Protein Structure. The nature, i.e., identity,
of the constituent amino acids and their sequence is referred to
as the primary structure. A primary structure will have a definite three
dimensional structure which is called the secondary structure (usually helical
coiling). The secondary structure of a large peptide or protein
is wrapped about and interwoven to develop the overall three dimensional
structure of the molecule. This arrangement of the secondary structure
is referred to as the tertiary structure and determines the alosteric
properties of many proteins. |
SEE OR SEARCH CLASS:
| 117, | Single-Crystal, Oriented-Crystal, and Epitaxy
Growth Processes; Non-Coating Apparatus Therefor, for processes for growing therein-defined single-crystal
of all types of materials, including inorganic or organic. |
| 424, | Drug, Bio-Affecting and Body Treating Compositions, has the following subclasses for proteins or proteinaceous
material 1.11+, for radionuclide or intended radionuclide
containing; 418, 456, 460, 477+, 491+, 499, 520+;
for a protein or peptide containing composition which functions
as an antiperspirant or deodorant; 85.1+ for a composition
containing a lymphokine; 130.1+ for a composition containing
an immunoglobulin, an antiserum, an antibody, or an antibody fragment; 184.1+ for
a composition containing an antigen, an epitope, or another immunospecific
immunoeffector that may be proteinaceous; 278.1+ for a composition
containing a nonspecific immunoeffector that may be proteinaceous;
94.1+, for compositions containing proteins identified
as enzymes; 520+, for compositions many of which are considered
to be proteinaceous; an animal extract of undetermined constitution;
115+ for compositions which may be proteins or peptides
identified by elemental analysis. |
| 430, | Radiation Imagery Chemistry: Process, Composition,
or Product Thereof,
subclasses 59 .6, 537, 539, 629, 640, 642, and 643 for compositions
containing proteins used in forming an image. |
| 435, | Chemistry: Molecular Biology and Microbiology,
subclasses 68.1+ for microbial or enzymatic synthesis of proteins
and peptides; subclasses 183+ for the production of enzymes; and
subclasses 74+ for the formation of immobilized enzymes
and subclasses 269 and 272+ for the liberation or purification
of proteins by means of a microorganism or enzyme, particularly
subclass 273 for the purification of collagen or gelatin. |
| 436, | Chemistry: Analytical and Immunological Testing,
subclass 15 for a protein containing composition used as a standard
or control; 16, for a blood standard; 66, for tests for hemoglobin or
myoglobin, 66 for test for blood clotting factor tests, 86+ for
tests for proteins or peptides including sequencing methods and
subclass 501 for a complement binding assay and protein binding
assays and subclasses 506-548 for tests using antigen antibody interactions
in a chemical test, particularly subclasses 543-548 which collect
methods of modifying antigens and antibodies as part of a testing
procedure. |
| 506, | Combinatorial Chemistry Technology: Method, Library,
Apparatus, for a peptide library or a method of making said
library. |
| 514, | Drug, Bio-Affecting and Body Treating Compositions,
subclasses 1 through 21and cross-reference art collections 800-809 which
provide for compositions having a 424 utility containing a peptide
or protein as an organic active ingredient. |
| 524, | Synthetic Resins or Natural Rubbers,
subclasses 9+ for plant or derived cellular material, subclasses
17+ for proteins or biologically active polypeptides for
a process in which the protein or polypeptide is physically mixed
with a preformed resin and subclasses 70+ for a process
of adding a protein or biologically active polypeptide to resin
forming ingredients during reaction of the resin formers and the
protein or polypeptide is nonreactive. |
| 525, | Synthetic Resins or Natural Rubbers,
subclass 54.1 for the chemical reaction of a peptide or protein
with a preformed resin and subclass 54.11 for processes of stepwise
assembly of a polypeptide on a preformed polymer, i.e., solid phase
synthesis when there is no claimed cleavage of the synthesized polypeptide. |
| 526, | Synthetic Resins or Natural Rubbers,
subclass 238.1 for the formation of a synthetic resin from a protein
or biologically active polypeptide where the protein or polypeptide
as well as all other reactants are ethylenically unsaturated. |
| 528, | Synthetic Resins or Natural Rubbers, particularly
subclass 328 for a polymer of amino acids and methods of making
such a polyamino acid. |
| 930, | Peptide or Protein Sequence,
subclasses 10+ for peptide or protein sequences of four or more
amino acids. |
|