CPC Definition - Subclass C07D
|Last Updated Version: 2018.01|
This place covers:
Organic compounds containing at least one heterocyclic ring, and with no ring comprising a steroid, saccharide or peptide moiety. Said compounds should generally comprise the following elements or periodic groups only, C, H, halogen, N, O, S, Se, Te.
The only exception to this requirement is that the compounds may contain metal atoms, but only as the cations of heterocyclic organic acid salts, alcoholates, phenolates or mercaptides, or as chelating atoms, e.g. in porphyrins.
Preparation of such compounds, including purification, separation, stabilisation or use of additives, unless a separate place is provided elsewhere in the classification scheme.
Rings are considered as "heterocycles" only if they contain at least one atom selected from halogen, N, O, S, Se or Te as a ring member. Heterocyclic rings may be present as distinct entities or condensed, either with carbocycles or among themselves.
Heterocyclic compounds having only nitrogen as ring hetero atom
Heterocyclic compounds having nitrogen and oxygen as the only ring hetero atoms
Heterocyclic compounds having nitrogen and sulfur as the only ring hetero atoms
Heterocyclic compounds having nitrogen and oxygen and sulfur as the only ring hetero atoms
Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
Heterocyclic compounds having oxygen atoms, with or without sulfur, selenium or tellurium atoms, as ring hetero atoms
Heterocyclic compounds having sulfur, selenium or tellurium atoms as the only ring hetero atoms
Heterocyclic compounds containing halogen as ring hetero atoms
Heterocyclic compounds containing two or more hetero rings (*)
Heterocyclic compounds containing condensed hetero ring systems (**)
C07D 521/00 Heterocyclic compounds containing unspecified hetero rings
Cover compounds containing two or more relevant hetero rings at least two of which are covered by different main groups of groups C07D 203/00- C07D 347/00, neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
Cover compounds containing one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system, with or without other non-condensed hetero rings.
Relationships with other classification places
In class C07, the last place priority rule is used, i.e. in the absence of an indication to the contrary, a compound is classified in the last appropriate subclass. Hence, while individual heterocycle-containing amino acids are classified in this subclass C07D, peptides are generally classified in subclass C07K. Similarly, compounds containing saccharide radicals are classified in subclass C07H, and heterocyclic steroids are classified in subclass C07J. (Detailed instructions which compounds are considered as C07H, C07J or C07K can be found in the corresponding CPC Definitions.) Heterocycles incorporating elements other than C, H, halogen, N, O, S, Se or Te are classified in subclass C07F, but only if the metal-containing compound has a metal carbon bond or if the metal is attached to at least two different ligands. Salts, chelates, alcoholates (except Ti/Zr), phenates involving a single ligand are classified as the parent compound (metal containing porphyrin C07D 487/22).
This subclass is a structure-oriented entry for the compounds themselves and does not cover the application or use of the compounds under the subclass definition.
For classifying such information other entries exist, for example:
Biocidal, pest attractant, or plant growth regulatory activity of chemical compounds or preparations is further classified in subclass A61P. Uses of cosmetics or similar toilet preparations are further classified in subclass A61Q.(this subclass does only exist in IPC).Therapeutic activity of chemical compounds is further classified in subclass
This place does not cover:
Attention is drawn to the following places, which may be of interest for search:
Special rules of classification
In this subclass, in the absence of an indication to the contrary, a compound is classified in the last appropriate place.
Chemical compounds and their preparation are classified in the groups for the type of compound prepared. The processes of preparation are also classified in the groups for the types of reaction employed, if of interest. The compounds prepared are also classified in the groups for the types of compounds prepared, if of interest.
Salts of a compound, unless specifically provided for, are classified as that compound. Salts, adducts or complexes formed between two or more organic compounds are classified according to all compounds forming the salts, adducts or complexes.
Where a molecule may exist in tautomeric forms, classification is made for the form which appears latest in the scheme. Therefore, double bonds between ring members and non-ring members and double bonds between ring members themselves are considered equivalent in determining the degree of hydrogenation of the ring.
Compounds containing a single heterocycle are classified in the range C07D 203/00-C07D 347/00 (cf. Table 1). Compounds containing two or more heterocycles, none of which are condensed among themselves nor condensed with a carbocyclic ring, and all of which are covered by the same main group, are also classified in this range.
Compounds containing two or more hetero rings individually covered by different main groups, and not part of the same condensed ring system are classified in the range C07D 401/00-C07D 421/00 (cf. Table 2).
Heterocyclic compounds which contain rings of five or more members, wherein only nitrogen is present as a ring heteroatom, and wherein the ring carbon atoms are fully saturated and only bound to hydrogen atoms, are classified in main group C07D 295/00. Morpholines and thiomorpholines unsubstituted on the ring carbon atoms are also classified here.
An acyclic side-chain linked to the hetero ring is considered to be terminated by every bond to: 1) an element other than carbon 2) a carbon atom having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals. For example, the compound:
is classified in C07D 203/10 and not in C07D 203/12
Where a heterocycle is linked to a carbocycle by an acyclic chain, and both the chain and the carbocycle are further substituted by either hetero atoms or carbon atoms with three bonds to hetero atoms, not more than one hetero atom being a halogen, the molecule is classified according to the substituents on the acyclic chain. See the following example:
is classified in group C07D 233/22, and the compound
is classified in groups C07D 233/24 and C07D 233/26, where X = - NH2, - NHCOCH3, or - COOCH3.
C07D 451/00-C07D 517/00 cover compounds containing one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system, with or without other non- condensed hetero rings. For the purpose of classification in groups C07D 451/00-C07D 519/00, the degree of hydrogenation of the ring system is not taken into consideration. For the purpose of classification in groups C07D 451/00 C07D 463/00, C07D 473/00-C07D 477/00, C07D 489/00, C07D 499/00-C07D 507/00, the wording of the groups has to be understood, in the absence of an indication to the contrary, as including ring systems further condensed with carbocyclic rings or ring systems, but excluding ring systems further condensed with other hetero rings, either directly or through a common carbocyclic ring system, e.g. sparteine is classified in group C07D 471/22, not in group C07D 455/02. In groups C07D 471/00, C07D 487/00, C07D 491/00-C07D 498/00 or C07D 513/00-C07D 517/00, the subdivision is based on the number of relevant hetero rings.
Where a compound contains at least one ring covered by group C07D 295/00 and at least one other hetero ring, the hetero ring covered by group C07D 295/00 is treated as an acyclic chain containing nitrogen atoms for the purposes of classification and is not considered to be a hetero ring in this context.Thus, e.g.
C07D 295/02, and NOT C07D 413/06 and
C07D 213/74, and NOT C07D 401/04
C07D 405/12, and NOT C07D 405/14
What is classified as a compound?
Classified are real examples of claimed compounds, i.e. those which are prepared or for which physical data are given, and which are individually named or drawn in the claims. The same applies for compounds disclosed as reaction intermediates.
Not classified are generic formulae (Markush formulae, even if they have only one variable group), lists of "prophetic compounds" which fall within the scope of the claims but which were not actually prepared and compounds disclosed in the description but which are not claimed as compounds per se.
What is classified as a process for the preparation of a compound?
Classified are only preparation examples of claimed processes. A process is classified in a process group if a dedicated process group exists (e.g. C07D 201/00 or C07D 301/00). Where there is no process group for making a particular compound the process is classified according to the product obtained in the claimed process.
Further classification information:
Tables 1-4 provide an overview of the main groups in C07D.
Structural chemical formulae for various subgroups (in particular for specific ring systems as shown in table 3 below) are available in the classification scheme on the WIPO web-site.
NOTES to Table 1:
condensed derivatives are together with the parent hetero ring, unless a specific main group is provided
the relative position of the hetero atoms in the hetero ring is given between brackets
Table 3: Overview of specific condensed systems:
Table 4: Overview of other condensed systems:
(compounds of Table 3 take precedence)
Glossary of terms
In this place, the following terms or expressions are used with the meaning indicated:
Heterocyclic compounds containing unspecified hetero rings
Special rules of classification