	US 11,903,709 C1 (13,407th)
	Fluid control devices and methods of using the same
Gregory J. Bullington, Seattle, WA (US); Jay M. Miazga, Langley, WA (US); Shan E. Gaw, Seattle, WA (US); and Timothy F. Ramsey, Seattle, WA (US)
Filed by Magnolia Medical Technologies, Inc., Seattle, WA (US)
Assigned to Magnolia Medical Technologies
Reexamination Request No. 90/019,824, Jan. 21, 2025.
Reexamination Certificate for Patent 11,903,709, issued Feb. 20, 2024, Appl. No. 18/130,207, Apr. 3, 2023.
Application 90/019,824 is a continuation of application No. 17/883,340, filed on Aug. 8, 2022, granted, now 11,653,863.
Application 17/883,340 is a continuation of application No. 17/390,249, filed on Jul. 30, 2021, granted, now 12,290,363.
Application 17/390,249 is a continuation of application No. 16/129,066, filed on Sep. 12, 2018, granted, now 11,076,787.
Claims priority of provisional application 62/678,632, filed on May 31, 2018.
Claims priority of provisional application 62/634,569, filed on Feb. 23, 2018.
Claims priority of provisional application 62/557,530, filed on Sep. 12, 2017.
Ex Parte Reexamination Certificate issued on Oct. 2, 2026.
Int. Cl. A61B 5/15 (2006.01); B01L 3/00 (2006.01)

CPC A61B 5/150946 (2013.01) [A61B 5/15003 (2013.01); A61B 5/150099 (2013.01); A61B 5/150213 (2013.01); A61B 5/150221 (2013.01); A61B 5/150251 (2013.01); A61B 5/150992 (2013.01); B01L 3/502 (2013.01); B01L 2200/026 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/0689 (2013.01); B01L 2200/141 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/14 (2013.01); B01L 2400/0478 (2013.01); B01L 2400/0487 (2013.01)]

Attention is directed to the decision of 1:24cv1124 Magnolia Medical Technologies, Inc. v. Kurin, Inc U.S. District Court Delaware.; 3:24cv428 Magnolia Medical Technologies, Inc. v. Kurin, Inc. U.S. District Court Southern California.; 1:19cv00097 Magnolia Medical Technologies, Inc. v. Kurin, Inc U.S. District Court Delaware relating to this patent. This reexamination may not have resolved all questions raised by these decisions. See 37 CFR 1.552(c) for ex parte reexamination and 37 CFR 1.906(c) for inter partes reexamination.

AS A RESULT OF REEXAMINATION, IT HAS BEEN DETERMINED THAT:

The patentability of claims 1-27 is confirmed.

Claims 28-29 are determined to be patentable as amended.

Claim 30, dependent on an amended claim, is determined to be patentable.

New claims 31-144 are added and determined to be patentable.

1. A fluid control device, the device comprising:

a housing having an inlet fluidically coupleable to a blood source and an outlet fluidically coupleable to a fluid collection device, the housing defining at least a portion of each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier, the blood barrier fluidically coupled to the containment channel and the outlet; and

a valve disposed at least partially in the housing and configured to substantially obstruct a flow path between the inlet and the outlet when in a first state;

the blood barrier configured to allow a gas to flow through the blood barrier in response to a pressure differential between the inlet and the outlet, thereby allowing a volume of blood to flow into the containment channel,

in response to contact with at least a portion of the volume of the blood in the containment channel, the blood barrier configured to allow the pressure differential in at least a portion of the sampling channel between the valve and the outlet to build to an extent sufficient to transition the valve from the first state to a second state in which the valve allows blood to flow through the sampling channel to the outlet.

28. A fluid control device, the device comprising:

a containment channel defined between an inlet and an outlet;

a sampling channel defined between the inlet and the outlet;

[ a housing defining at least a portion of each of the containment channel and the sampling channel between the inlet and the outlet;]

a selectively permeable blood barrier at a proximal end portion of the containment channel, the blood barrier configured to allow a gas to flow from the containment channel to the outlet in response to a pressure differential between the inlet and the outlet such that a volume of blood flows from a blood source, through the inlet, and into the containment channel; and

a valve in fluidic communication with at least a portion of the containment channel and sampling channel, the valve in a first state configured to prevent the blood from flowing from the inlet to the outlet via the sampling channel, the valve configured to transition to a second state in response to a pressure differential in at least a portion of the sampling channel between the valve and the outlet exceeding a threshold pressure as a result of the volume of blood in the containment channel, the valve in the second state configured to allow blood to flow through the sampling channel to the outlet.

29. The device of claim 28, wherein the valve is configured to open in response to a predetermined pressure ~~valve~~.

[ 31. The device of claim 1, wherein the containment channel comprises a stationary channel defined by the housing between the valve and the selectively permeable blood barrier.]

[ 32. The device of claim 1, wherein the outlet is configured to be coupled to a sample collection container such that a drawing force from the sample collection container causes the pressure differential.]

[ 33. The device of claim 1, wherein the selectively permeable blood barrier is stationarily attached to the housing.]

[ 34. The device of claim 10, wherein the containment channel comprises a stationary channel defined by the housing between the valve and the selectively permeable blood barrier.]

[ 35. The device of claim 10, wherein the outlet is configured to be coupled to a sample collection container such that a drawing force from the sample collection container causes the pressure differential between the valve and the outlet.]

[ 36. The device of claim 10, wherein the selectively permeable blood barrier is stationarily attached to the housing.]

[ 37. The device of claim 19, wherein the containment channel comprises a stationary channel defined by the housing between the valve and the selectively permeable blood barrier.]

[ 38. The device of claim 19, wherein the outlet is configured to be coupled to a sample collection container such that a drawing force from the sample collection container causes the first pressure differential and the second pressure differential.]

[ 39. The device of claim 19, wherein the selectively permeable blood barrier is stationarily attached to the housing.]

[ 40. The device of claim 28, wherein the containment channel comprises a stationary channel defined by a device housing between the valve and the selectively permeable blood barrier.]

[ 41. The device of claim 28, wherein the outlet is configured to be coupled to a sample collection container such that a drawing force from the sample collection container causes the first pressure differential and the second pressure differential.]

[ 42. The device of claim 28, wherein the selectively permeable blood barrier is stationarily attached to a device housing.]

[ 43. A fluid control device, the device comprising:

a housing having an inlet fluidically coupleable to a blood source and an outlet fluidically coupleable to a fluid collection device, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier, the blood barrier fluidically coupled to the containment channel and the outlet, and stationarily attached to the housing; and

a valve disposed in the housing, distal to the selectively permeable blood barrier and configured to substantially obstruct a fluid flow path between the inlet and the outlet when in a first state,

the blood barrier configured to facilitate flow of a gas through the blood barrier in response to a pressure differential, based on a drawing force at the outlet, between the inlet and the outlet, thereby allowing a volume of blood to flow into the containment channel,

wherein the blood barrier is configured to cause, in response to contact with at least a portion of the volume of the blood in the containment channel, the pressure differential, based on the drawing force at the outlet, in at least a portion of the sampling channel between the valve and the outlet to build to an extent that transitions the valve from the first state to a second state in which the valve allows blood to flow through the sampling channel to the outlet.]

[ 44. The device of claim 43, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 45. The device of claim 43, wherein the valve is a one-way valve.]

[ 46. The device of claim 43, wherein the housing defines at least a portion of a flow path between a proximal end portion of the containment channel and the outlet, at least a portion of the flow path is configured to modulate the pressure differential between the inlet and the outlet as the volume of blood is drawn into the containment channel.]

[ 47. The device of claim 43, wherein the valve in the second state is configured to allow blood to flow from the blood source to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 48. The device of claim 43, wherein the valve is formed of an elastomeric material.]

[ 49. The device of claim 43, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 50. A fluid control device, the device comprising:

a selectively permeable blood barrier, the blood barrier fluidically coupled to the containment channel and the outlet, wherein the blood barrier is attached to the housing; and

a valve disposed at least partially in the housing and configured to substantially obstruct a gas and liquid flow path between the inlet and the outlet when in a first state,

wherein the blood barrier is configured to cause, in response to contact with at least a portion of the volume of the blood in the containment channel, the pressure differential, based on the drawing force at the outlet, in at least a portion of the sampling channel between the valve and the outlet to build to an extent sufficient to transition the valve from the first state to a second state in which the valve allows blood to flow through the sampling channel to the outlet.]

[ 51. The device of claim 50, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 52. The device of claim 50, wherein the valve is a one-way valve.]

[ 53. The device of claim 50, wherein the housing defines at least a portion of a flow path between a proximal end portion of the containment channel and the outlet, at least a portion of the flow path is configured to modulate the pressure differential between the inlet and the outlet as the volume of blood is drawn into the containment channel.]

[ 54. The device of claim 50, wherein the valve in the second state is configured to allow blood to flow from the blood source to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 55. The device of claim 50, wherein the valve is formed of an elastomeric material.]

[ 56. The device of claim 50, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 57. A fluid control device, the device comprising:

a selectively permeable blood barrier, the blood barrier fluidically coupled to the containment channel and the outlet and attached to the housing; and

a valve, substantially impermeable to gas and liquid, disposed at least partially in the housing and configured to substantially obstruct a gas and liquid flow path between the inlet and the outlet when in a first state,

the blood barrier configured to facilitate flow of a gas through the blood barrier in response to a pressure differential, based on a drawing force from the fluid collection device at the outlet, between the inlet and the outlet, thereby allowing a volume of blood to flow into the containment channel,

wherein the blood barrier is further configured to cause, in response to contact with at least a portion of the volume of the blood in the containment channel, the pressure differential, based on a drawing force at the outlet, in at least a portion of the sampling channel between the valve and the outlet to build to an extent that transitions the valve from the first state to a second state in which at least a portion of the valve moves away from the containment channel and towards the sampling channel, to allow blood to flow through the sampling channel to the outlet.]

[ 58. The device of claim 57, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 59. The device of claim 57, wherein the valve is a one-way valve.]

[ 60. The device of claim 57, wherein the housing defines at least a portion of a flow path between a proximal end portion of the containment channel and the outlet, at least a portion of the flow path is configured to modulate the pressure differential between the inlet and the outlet as the volume of blood is drawn into the containment channel.]

[ 61. The device of claim 57, wherein the valve in the second state is configured to allow blood to flow from the blood source to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 62. The device of claim 57, wherein the valve is formed of an elastomeric material.]

[ 63. The device of claim 57, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 64. A fluid control device, the device comprising:

a selectively permeable blood barrier, the blood barrier fluidically coupled to the containment channel and the outlet and attached to the housing; and

a valve disposed at least partially in the housing and configured to substantially obstruct a gas and liquid flow path between the inlet and the outlet when in a first state,

wherein the valve is disposed at a junction between the containment channel and the sampling channel when in the first state,

wherein the blood barrier is configured to facilitate flow of a gas through the blood barrier in response to a pressure differential, based on a drawing force at the outlet, between the inlet and the outlet, thereby allowing a volume of blood to flow into the containment channel,

wherein, the blood barrier is further configured to cause, in response to contact with at least a portion of the volume of the blood in the containment channel, the pressure differential, based on the drawing force at the outlet, in at least a portion of the sampling channel between the valve and the outlet to build to an extent that transitions the valve from the first state to a second state in which at least a portion of the valve moves towards the sampling channel proximate the junction, to allow blood to flow from the inlet through the sampling channel to the outlet.]

[ 65. The device of claim 64, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 66. The device of claim 64, wherein the valve is a one-way valve.]

[ 67. The device of claim 64, wherein the housing defines at least a portion of a flow path between a proximal end portion of the containment channel and the outlet, at least a portion of the flow path is configured to modulate the pressure differential between the inlet and the outlet as the volume of blood is drawn into the containment channel.]

[ 68. The device of claim 64, wherein the valve in the second state is configured to allow blood to flow from the blood source to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 69. The device of claim 64, wherein the valve is formed of an elastomeric material.]

[ 70. The device of claim 64, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 71. A fluid control device, the device comprising:

a selectively permeable blood barrier, the blood barrier fluidically coupled to the containment channel and the outlet; and

a valve disposed at least partially in the housing and configured to substantially obstruct a gas and liquid flow path between the inlet and the outlet when in a first state,

wherein the containment channel comprises a stationary channel defined by the housing between the valve and the selectively permeable blood barrier,

wherein the blood barrier is further configured to cause, in response to contact with at least a portion of the volume of the blood in the containment channel, the pressure differential, based on the drawing force at the outlet, in at least a portion of the sampling channel between the valve and the outlet to build to an extent that transitions the valve from the first state to a second state in which the valve allows blood to flow from the inlet through the sampling channel to the outlet, and

wherein the valve is configured to be at least temporarily locked in the second state.]

[ 72. The device of claim 71, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 73. The device of claim 71, wherein the valve is a one-way valve.]

[ 74. The device of claim 71, wherein the housing defines at least a portion of a flow path between a proximal end portion of the containment channel and the outlet, at least a portion of the flow path is configured to modulate the pressure differential between the inlet and the outlet as the volume of blood is drawn into the containment channel.]

[ 75. The device of claim 71, wherein the valve in the second state is configured to allow blood to flow from the blood source to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 76. The device of claim 71, wherein the valve is formed of an elastomeric material.]

[ 77. The device of claim 71, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 78. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier stationarily disposed at least partially in and attached to the housing, and in fluidic communication with the containment channel and the outlet, the blood barrier configured to facilitate flow of a gas to flow from the containment channel to the outlet in response to a pressure differential between the inlet and the outlet such that a volume of blood flows from the inlet into the containment channel; and

a valve disposed at least partially in the housing distal to the selectively permeable blood barrier and between at least a portion of the sampling channel and the inlet, wherein the valve in a first state configured to prevent the volume of blood from flowing from the inlet to the outlet, the valve configured to transition from the first state to a second state in response to an increase in a pressure differential, based on a drawing force at the outlet, between the valve and the outlet as a result of the volume of blood in the containment channel such that a subsequent volume of blood is drawn from the inlet through the sampling channel and to the outlet.]

[ 79. The device of claim 78, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 80. The device of claim 78, wherein the valve is a one-way valve.]

[ 81. The device of claim 78, further comprising:

a flow path between a proximal end portion of the containment channel and the outlet, at least a portion of the flow path is configured to modulate the pressure differential between the inlet and the outlet as the volume of blood is drawn into the containment channel.]

[ 82. The device of claim 78, wherein the valve in the second state is configured such that the subsequent volume of blood is drawn from the inlet to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 83. The device of claim 78, wherein the valve is formed of an elastomeric material.]

[ 84. The device of claim 78, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 85. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier disposed in and attached to the housing in fluidic communication with the containment channel and the outlet, the blood barrier configured to facilitate flow of a gas from the containment channel to the outlet in response to a pressure differential between the inlet and the outlet such that a volume of blood flows from the inlet into the containment channel; and

a valve disposed at least partially in the housing between at least a portion of the sampling channel and the inlet, wherein the valve in a first state is configured to prevent air and the volume of blood from flowing from the inlet to the outlet, the valve configured to transition from the first state to a second state in response to an increase in a pressure differential, based on a drawing force at the outlet, between the valve and the outlet as a result of the volume of blood in the containment channel such that a subsequent volume of blood is drawn from the inlet through the sampling channel and to the outlet.]

[ 86. The device of claim 85, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 87. The device of claim 85, wherein the valve is a one-way valve.]

[ 88. The device of claim 85, further comprising:

[ 89. The device of claim 85, wherein the valve in the second state is configured such that the subsequent volume of blood is drawn from the inlet to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 90. The device of claim 85, wherein the valve is formed of an elastomeric material.]

[ 91. The device of claim 85, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 92. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier disposed in and stationarily attached to the housing, and in fluidic communication with the containment channel and the outlet, the blood barrier configured to facilitate flow of a gas from the containment channel to the outlet in response to a pressure differential between the inlet and the outlet such that a volume of blood flows from the inlet into the containment channel; and

a valve disposed at least partially in the housing between at least a portion of the sampling channel and the inlet, the valve in a first state configured to prevent air and the volume of blood from flowing from the inlet to the outlet, and wherein the valve configured to transition from the first state to a second state, such that at least a portion of the valve moves away from the containment channel towards the sampling channel, in response to an increase in a pressure differential, based on a drawing force at the outlet, between the valve and the outlet as a result of the volume of blood in the containment channel such that a subsequent volume of blood is drawn from the inlet through the sampling channel and to the outlet.]

[ 93. The device of claim 92, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 94. The device of claim 92, wherein the valve is a one-way valve.]

[ 95. The device of claim 92, further comprising:

[ 96. The device of claim 92, wherein the valve in the second state is configured such that the subsequent volume of blood is drawn from the inlet to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 97. The device of claim 92, wherein the valve is formed of an elastomeric material.]

[ 98. The device of claim 92, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 99. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a valve disposed at a junction in the housing between sampling channel and the inlet, wherein the valve in a first state is configured to prevent gas and the volume of blood from flowing from the inlet to the outlet, and wherein the valve is configured to transition from the first state to a second state, such that at least portion of the valve moves towards the sampling channel proximate the junction, in response to an increase in a pressure differential, based on a drawing force at the outlet, between the valve and the outlet as a result of the volume of blood in the containment channel such that a subsequent volume of blood is drawn from the inlet through the sampling channel and to the outlet.]

[ 100. The device of claim 99, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 101. The device of claim 99, wherein the valve is a one-way valve.]

[ 102. The device of claim 99, further comprising:

[ 103. The device of claim 99, wherein the valve in the second state is configured such that the subsequent volume of blood is drawn from the inlet to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 104. The device of claim 99, wherein the valve is formed of an elastomeric material.]

[ 105. The device of claim 99, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 106. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier disposed at least partially in the housing in fluidic communication with the containment channel and the outlet, the blood barrier configured to facilitate flow of a gas from the containment channel to the outlet in response to a pressure differential between the inlet and the outlet such that a volume of blood flows from the inlet into the containment channel; and

a valve disposed in the housing between at least a portion of the sampling channel and the inlet,

wherein the containment channel comprises a stationary channel defined by the housing between the valve and the selectively permeable blood barrier,

wherein the valve in a first state is configured to prevent gas and the volume of blood from flowing from the inlet to the outlet,

wherein the valve is configured to transition from the first state to a second state in response to an increase in a pressure differential, based on a drawing force at the outlet, between the valve and the outlet as a result of the volume of blood in the containment channel such that a subsequent volume of blood is drawn from the inlet through the sampling channel and to the outlet, and

wherein the valve is configured to be at least temporarily locked in the second state.]

[ 107. The device of claim 106, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 108. The device of claim 106, wherein the valve is a one-way valve.]

[ 109. The device of claim 106, further comprising:

[ 110. The device of claim 106, wherein the valve in the second state is configured such that the subsequent volume of blood is drawn from the inlet to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 111. The device of claim 106, wherein the valve is formed of an elastomeric material.]

[ 112. The device of claim 106, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 113. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing at least partially defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier disposed at least partially in the housing in fluidic communication with the containment channel and the outlet, the blood barrier configured to allow a gas to flow from the containment channel to the outlet in response to a pressure differential between the inlet and the outlet such that a volume of blood flows from the inlet into the containment channel; and

a one-way valve, formed of an elastomeric material, disposed at least partially in the housing between at least a portion of the sampling channel and the inlet, the one-way valve in a first state configured to prevent the volume of blood from flowing from the inlet to the outlet, the one-way valve configured to transition from the first state to a second state in response to an increase in a pressure differential between the one-way valve and the outlet as a result of the volume of blood in the containment channel such that a subsequent volume of blood is drawn from the inlet through the sampling channel and to the outlet while at least a portion of the volume of blood is contained in the containment channel.]

[ 114. The device of claim 113, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 115. The device of claim 113, further comprising:

[ 116. The device of claim 113, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 117. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier, the blood barrier stationarily disposed in the housing between the containment channel and the outlet and attached to the housing; and

a valve disposed in the housing between at least a portion of the sampling channel and the inlet,

wherein the blood barrier is configured to facilitate flow of a gas from the containment channel to the outlet in response to a first pressure differential between the inlet and the outlet such that a volume of blood flows into the containment channel,

wherein the valve is configured to transition from a first state to a second state in response to a second pressure differential greater than the first pressure differential, based on a drawing force at the outlet, between the valve and the outlet as a result of the volume of blood in the containment channel, and

wherein the valve in the first state is configured to prevent gas and the volume of blood from flowing from the inlet to the outlet via the sampling channel and the valve in the second state is configured to allow a subsequent volume of blood to flow from the inlet through the sampling channel to the outlet.]

[ 118. The device of claim 117, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 119. The device of claim 117, wherein the valve is a one-way valve.]

[ 120. The device of claim 117, further comprising:

[ 121. The device of claim 117, wherein the valve in the second state is configured such that the subsequent volume of blood is drawn from the inlet to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 122. The device of claim 117, wherein the valve is formed of an elastomeric material.]

[ 123. The device of claim 117, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 124. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier, the blood barrier disposed at least partially in the housing between the containment channel and the outlet and attached to the housing; and

a valve disposed in the housing before the containment channel from the inlet and between at least a portion of the sampling channel and the inlet,

wherein the blood barrier is configured to facilitate flow of a gas to flow from the containment channel to the outlet in response to a first pressure differential, based on a drawing force at the outlet, between the inlet and the outlet such that a volume of blood flows into the containment channel,

wherein the valve is configured to transition from a first state to a second state in response to a second pressure differential greater than the first pressure differential, based on the drawing force at the outlet, between the valve and the outlet as a result of the volume of blood in the containment channel, and

wherein the valve in the first state is configured to prevent the volume of blood from flowing from the inlet to the outlet via the sampling channel, and the valve in the second state is configured to allow a subsequent volume of blood to flow from the inlet through the sampling channel to the outlet.]

[ 125. The device of claim 124, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 126. The device of claim 124, wherein the valve is a one-way valve.]

[ 127. The device of claim 124, further comprising:

[ 128. The device of claim 124, wherein the valve in the second state is configured such that the subsequent volume of blood is drawn from the inlet to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 129. The device of claim 124, wherein the valve is formed of an elastomeric material.]

[ 130. The device of claim 124, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 131. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier, the blood barrier disposed at least partially in the housing between the containment channel and the outlet and attached to the housing; and

a valve disposed in the housing at a junction between the inlet, the containment channel, and the sampling channel, and disposed between at least a portion of the sampling channel and the inlet,

wherein the blood barrier is configured to facilitate flow of a gas from the containment channel to the outlet in response to a first pressure differential, based on a drawing force at the outlet, between the inlet and the outlet such that a volume of blood flows into the containment channel,

wherein the valve is configured to transition from a first state to a second state, such that at least a portion of the valve moves into the sampling channel proximate the junction, in response to a second pressure differential greater than the first pressure differential, based on the drawing force at the outlet, between the valve and the outlet as a result of the volume of blood in the containment channel, and

wherein the valve in the first state is configured to prevent air and the volume of blood from flowing from the inlet to the outlet via the sampling channel, and the valve in the second state is configured to allow a subsequent volume of blood to flow from the inlet through the sampling channel to the outlet.]

[ 132. The device of claim 131, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 133. The device of claim 131, wherein the valve is a one-way valve.]

[ 134. The device of claim 131, further comprising:

[ 135. The device of claim 131, wherein the valve in the second state is configured such that the subsequent volume of blood is drawn from the inlet to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 136. The device of claim 131, wherein the valve is formed of an elastomeric material.]

[ 137. The device of claim 131, wherein the valve is configured to automatically transition from the first state to the second state.]

[ 138. A fluid control device, the device comprising:

a housing having an inlet and an outlet, the housing defining each of a containment channel and a sampling channel between the inlet and the outlet;

a selectively permeable blood barrier, the blood barrier disposed at least partially in the housing between the containment channel and the outlet and attached to the housing; and

a valve disposed at least partially in the housing between at least a portion of the sampling channel and the inlet,

wherein the containment channel comprises a stationary channel defined by the housing between the valve and the selectively permeable blood barrier,

wherein the valve is configured to transition from a first state to a second state in response to a second pressure differential, based on the drawing force at the outlet, greater than the first pressure differential between the valve and the outlet as a result of the volume of blood in the containment channel, and

[ 139. The device of claim 138, wherein the valve is configured to open in response to a predetermined pressure differential.]

[ 140. The device of claim 138, wherein the valve is a one-way valve.]

[ 141. The device of claim 138, further comprising:

[ 142. The device of claim 138, wherein the valve in the second state is configured such that the subsequent volume of blood is drawn from the inlet to the outlet via the sampling channel while at least a portion of the volume of blood is contained in the containment channel.]

[ 143. The device of claim 138, wherein the valve is formed of an elastomeric material.]

[ 144. The device of claim 138, wherein the valve is configured to automatically transition from the first state to the second state.]