US 9,812,307 B2
Targeted mass analysis
Alexander Alekseevich Makarov, Bremen (DE)
Assigned to Thermo Fisher Scientific (Bremen) GmbH, Bremen (DE)
Appl. No. 15/21,108
Filed by Thermo Fisher Scientific (Bremen) GmbH, Bremen (DE)
PCT Filed Sep. 10, 2014, PCT No. PCT/EP2014/069320
§ 371(c)(1), (2) Date Mar. 10, 2016,
PCT Pub. No. WO2015/036447, PCT Pub. Date Mar. 19, 2015.
Claims priority of application No. 1316164.1 (GB), filed on Sep. 11, 2013.
Prior Publication US 2016/0217985 A1, Jul. 28, 2016
Int. Cl. H01J 49/40 (2006.01); H01J 49/00 (2006.01)
CPC H01J 49/005 (2013.01) [H01J 49/009 (2013.01); H01J 49/0036 (2013.01); H01J 49/0077 (2013.01); H01J 49/40 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A mass spectrometer, comprising:
an ion source, arranged to generate ions having an initial range of mass-to-charge ratios;
an auxiliary ion detector, located downstream from the ion source and arranged to receive a plurality of first ion samples having a reduced range of mass-to-charge ratios that is narrower than the initial range derived from the ions generated by the ion source and to determine a respective ion current measurement for each of the plurality of first ion samples;
a mass analyser, located downstream from the ion source and arranged to receive a second ion sample derived from the ions generated by the ion source and to generate mass spectral data by mass analysis of the second ion sample, wherein a resolution of the mass spectral data is high enough to mass resolve the ion current measurement determined by the auxiliary ion detector within the reduced range of mass-to-charge ratios; and
a processor configured to establish an abundance measurement associated with at least some of the ions generated by the ion source based on a combination of the mass spectral data generated by the mass analyser and the ion current measurements determined by the auxiliary ion detector, wherein the mass spectral data is used to mass resolve the ion current measurements within the reduced range of mass-to-charge ratios.