US 9,810,695 B2
Markers for preeclampsia
Vesna D. Garovic, Rochester, MN (US)
Assigned to Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed by Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed on Jan. 17, 2017, as Appl. No. 15/408,084.
Application 15/408,084 is a continuation of application No. 14/733,521, filed on Jun. 8, 2015, granted, now 9,557,342.
Application 14/733,521 is a continuation of application No. 14/312,980, filed on Jun. 24, 2014, abandoned.
Application 14/312,980 is a continuation of application No. 14/032,361, filed on Sep. 20, 2013, abandoned.
Application 14/032,361 is a continuation of application No. 12/274,117, filed on Nov. 19, 2008, abandoned.
Application 12/274,117 is a continuation in part of application No. 12/137,350, filed on Jun. 11, 2008, abandoned.
Claims priority of provisional application 60/943,242, filed on Jun. 11, 2007.
Prior Publication US 2017/0122960 A1, May 4, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/536 (2006.01); G01N 33/80 (2006.01); G01N 33/68 (2006.01)
CPC G01N 33/689 (2013.01) [G01N 33/536 (2013.01); G01N 33/80 (2013.01); G01N 2800/368 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A method for avoiding unnecessary treatment of preeclampsia, said method comprising:
(a) contacting a urine sample collected from a pregnant human during gestational week 18 to 36 with an antibody under conditions that allow binding of said antibody to a podocyte or a fragment of said podocyte, wherein, when said urine sample contains podocytes or fragments of said podocytes, antibody complexes comprising said antibody and said podocyte or a fragment of said podocyte are formed,
(b) detecting an absence of an elevated level of said antibody complexes as compared to corresponding urine levels from pregnant humans lacking preeclampsia, and
(c) proceeding with treatment of said pregnant human in a manner that avoids unnecessary treatment of preeclampsia based on the urine levels of said antibody complexes detected in step (a) in said pregnant human.