US 9,810,680 B2
Nanogap electronic detector for measuring properties of a biomolecule stretched in a nanochannel, and method thereof
Stephen Y. Chou, Princeton, NJ (US); and Xiaogan Liang, Princeton, NJ (US)
Assigned to Nanonex Corporation, Monmouth Junction, NJ (US)
Filed by Stephen Y. Chou, Princeton, NJ (US); and Xiaogan Liang, Princeton, NJ (US)
Filed on Apr. 16, 2010, as Appl. No. 12/761,867.
Claims priority of provisional application 61/170,008, filed on Apr. 16, 2009.
Prior Publication US 2010/0267158 A1, Oct. 21, 2010
Int. Cl. G01N 27/00 (2006.01); G01N 33/487 (2006.01); B82Y 35/00 (2011.01); C12Q 1/68 (2006.01); B01L 3/00 (2006.01)
CPC G01N 33/48721 (2013.01) [B01L 3/502761 (2013.01); B82Y 35/00 (2013.01); C12Q 1/68 (2013.01); B01L 3/502707 (2013.01); B01L 2200/0663 (2013.01); B01L 2300/0877 (2013.01); Y10T 436/143333 (2015.01)] 42 Claims
OG exemplary drawing
1. A method for measuring a property of a biomolecule in the solution, comprising:
drawing the solution that contains a biomolecule into a nanofluidic channel that has a nanogap detector positioned inside or adjacent to the nanofluidic channel, wherein the nanofluidic channel having a geometry with a width, a height and a length that confines and stretches the biomolecule within the channel and wherein the nanogap detector comprises two electrodes separated by a gap that is equal to or less than 20 nm;
passing the biomolecule through the gap of the nanogap detector; and
measuring an electrical output from the nanogap detector responsive to the passing of the biomolecule through said gap, wherein the output is a representative of a property of the biomolecule;
wherein the biomolecule is selected from the group consisting of DNAs, other nucleic acids, and any combination thereof.