US 9,810,664 B2
Ion mobility spectrometer and method of operating same
David Edward Clemmer, Bloomington, IN (US); Michael A. Ewing, Bloomington, IN (US); Steven M. Zucker, Bloomington, IN (US); and Christopher R. P. Conant, Bloomington, IN (US)
Assigned to Indiana University Research and Technology Corporation, Indianapolis, IN (US)
Filed by Indiana University Research and Technology Corporation, Indianapolis, IN (US)
Filed on Mar. 31, 2016, as Appl. No. 15/87,255.
Application 15/087,255 is a continuation of application No. 14/815,313, filed on Jul. 31, 2015, granted, now 9,368,333.
Application 14/815,313 is a continuation of application No. 14/492,468, filed on Sep. 22, 2014, granted, now 9,129,782, issued on Sep. 8, 2015.
Application 14/492,468 is a continuation of application No. 13/844,901, filed on Mar. 16, 2013, granted, now 8,872,102, issued on Oct. 28, 2014.
Application 13/844,901 is a continuation in part of application No. 12/952,109, filed on Nov. 22, 2010, granted, now 8,513,591, issued on Aug. 20, 2013.
Application 12/952,109 is a continuation in part of application No. 12/357,198, filed on Jan. 21, 2009, granted, now 7,838,821, issued on Nov. 23, 2010.
Claims priority of provisional application 61/021,785, filed on Jan. 17, 2008.
Prior Publication US 2016/0216236 A1, Jul. 28, 2016
This patent is subject to a terminal disclaimer.
Int. Cl. H01J 49/00 (2006.01); G01N 27/62 (2006.01); H01J 49/26 (2006.01)
CPC G01N 27/622 (2013.01) [H01J 49/0031 (2013.01); H01J 49/26 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An ion mobility spectrometer comprising:
a linear drift tube partitioned into a plurality of cascaded drift tube segments, each defining an ion inlet at one end and an ion outlet at an opposite end, with an ion elimination region defined between the ion outlet and an ion inlet of each adjacent drift tube segment,
an ion source coupled to the ion inlet of a first one of the plurality of cascaded drift tube segments,
one of an ion detector and an ion inlet of another ion mobility spectrometer instrument arranged to receive ions exiting the drift tube,
a number, M, of electric field activation sources each operatively connected to one or more of the plurality of drift tube segments such that, when activated, each establishes a repulsive electric field in at least one of the first M ion elimination regions and in every following Mth ion elimination region, and also establishes an electric drift field in all remaining ion elimination regions and in all of the plurality of cascaded drift tube segments,
a control circuit including a memory having instructions stored therein that are executable by the control circuit to sequentially activate each of the number, M, of electric field activation sources for a time duration while deactivating the remaining number, M, of electric field activation sources to thereby cause only ions supplied by the ion source that have a predefined ion mobility or range of ion mobilities defined by the time duration to travel through the drift tube from the first one of the plurality of cascaded drift tube segment to a last one of the plurality of cascaded drift tube segments, to then, for one or more times, sequentially activate each of the number, M, of electric field activation sources for the time duration while deactivating the remaining number, M, of electric field activation sources in reverse order to thereby cause only ions having the predefined ion mobility or range of mobilities defined by the time duration to travel through the drift tube from the last one of the plurality of cascaded drift tube segments to the first one of the plurality of cascaded drift tube segment followed by sequentially activating each of the number, M, of electric field activation sources for the time duration while deactivating the remaining number, M, of electric field activation sources to thereby cause only ions having the predefined ion mobility or range of ion mobilities defined by the time duration to travel through the drift tube from the first one of the plurality of cascaded drift tube segments to the last one of the plurality of cascaded drift tube segments, and to then activate at least one of one or more of the M electric field activations sources and at least another electric field activation source to draw at least some of the ions having the predetermined ion mobility or range of ion mobilities out of the linear drift tube and into the one of the ion detector and the ion inlet of another ion mobility spectrometer.