US 9,810,663 B2
Devices and methods for containing molecules
Derek M. Stein, Boston, MA (US); Xu Liu, Santa Cruz, CA (US); and Mirna Mihovilovic Skanata, New York, NY (US)
Assigned to Brown University, Providence, RI (US)
Filed by Brown University, Providence, RI (US)
Filed on Jan. 26, 2015, as Appl. No. 14/605,626.
Prior Publication US 2016/0216234 A1, Jul. 28, 2016
Prior Publication US 2017/0176383 A9, Jun. 22, 2017
Int. Cl. G01N 27/447 (2006.01); C12N 15/10 (2006.01); C12Q 1/68 (2006.01); G01N 33/487 (2006.01)
CPC G01N 27/44791 (2013.01) [C12N 15/101 (2013.01); C12Q 1/6825 (2013.01); G01N 33/48721 (2013.01)] 19 Claims
OG exemplary drawing
 
17. A method, comprising:
contacting a first fluid having a first ionic strength with a first surface of a device, wherein
the first fluid comprises a molecule;
contacting a second fluid having a second ionic strength with a second surface of the device such that the molecule is urged into a cavity within the device, the cavity having a volume of between about 1 cubic micrometers and about 15 cubic micrometers; wherein
the first ionic strength and the second ionic strength are different.