US 9,810,661 B2
Carbon nanotube biofet with a local amplifier in a system array for analysis of biomarkers and method of analysis of same
Josh Shachar, Santa Monica, CA (US)
Assigned to Sensor Kinesis Corporation, Los Angeles, CA (US)
Filed by Pharmaco-Kinesis Corporation, Los Angeles, CA (US)
Filed on Feb. 18, 2015, as Appl. No. 14/625,445.
Prior Publication US 2016/0238553 A1, Aug. 18, 2016
Int. Cl. G01N 27/00 (2006.01); G01N 15/06 (2006.01); G01N 33/00 (2006.01); G01N 33/48 (2006.01); G01N 27/414 (2006.01); G01N 33/543 (2006.01); H01L 51/00 (2006.01); H01L 51/05 (2006.01)
CPC G01N 27/4145 (2013.01) [G01N 27/4146 (2013.01); G01N 33/5438 (2013.01); H01L 51/0049 (2013.01); H01L 51/0558 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A bioFET cell for measuring a time dependent characteristic of an analyte bearing fluid comprising:
a conductive source electrode;
a conductive drain electrode;
a semiconductive single wall carbon nanotube network layer extending between the source and drain electrodes and electrically coupled there between;
an first insulating layer disposed on the source and drain electrodes to prevent any electrochemical reaction with the source and drain electrodes and the analyte bearing fluid;
a conductive gate electrode insulatively spaced from and disposed over and extending between the source and drain electrodes;
a second insulating layer disposed between the gate and the source and drain electrodes;
a polymer layer disposed on and linked to the semiconductive single wall carbon nanotube network layer;
a layer of at least one selected antibody disposed on and linked to the polymer layer to functionalize the semiconductive single wall carbon nanotube network layer to a selected target biomarker corresponding to the at least one selected antibody so that electron transport into the semiconductive single wall carbon nanotube network layer is facilitated; and
a high impedance source follower amplifier coupled to the source electrode;
where the source, drain and gate electrodes with the carbon nanotube network layer form a defined channel through which the analyte bearing fluid may flow.