US 9,810,650 B2
Systems and methods for performing truncated-correlation photothermal coherence tomography
Andreas Mandelis, Scarborough (CA); and Sreekumar Kaiplavil, Sutton (GB)
Filed by Andreas Mandelis, Scarborough (CA); and Sreekumar Kaiplavil, Sutton (GB)
Filed on Oct. 20, 2014, as Appl. No. 14/518,984.
Prior Publication US 2016/0109393 A1, Apr. 21, 2016
Int. Cl. G01J 5/02 (2006.01); G01N 25/72 (2006.01); G01J 5/10 (2006.01); G01N 29/06 (2006.01); G01N 29/24 (2006.01); G01N 29/34 (2006.01); G01J 5/00 (2006.01)
CPC G01N 25/72 (2013.01) [G01J 5/10 (2013.01); G01N 29/0672 (2013.01); G01N 29/2418 (2013.01); G01N 29/343 (2013.01); G01J 2005/0077 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method of performing photothermal imaging, the method comprising:
generating an excitation chirped waveform comprising a chirped sequence of pulses;
controlling a laser according to the excitation chirped waveform, such that the laser emits a chirped sequence of laser pulses;
directing the chirped sequence of laser pulses onto a sample;
detecting, with an infrared camera, photothermal radiation emitted from the sample, thereby obtaining time-dependent photothermal signal data for each image pixel of the infrared camera;
generating a truncated chirped waveform comprising a chirped sequence of truncated pulses, wherein each truncated pulse has a pulsewidth less than that of the pulses of the excitation chirped waveform, and wherein
each truncated pulse is delayed by a pre-selected time delay relative to a corresponding pulse of the chirped sequence of pulses;
cross-correlating the time-dependent photothermal signal data with the truncated chirped waveform, thereby obtaining, for each pixel of the infrared camera, time-dependent cross-correlation data; and
generating image data based on the time-dependent cross-correlation data.