US 9,810,623 B2
Quantification of a change in assay
Roozbeh Ghaffari, Cambridge, MA (US); Alexander Aranyosi, Medford, MA (US); and Stephen Lee, Cambridge, MA (US)
Assigned to MC10, Inc., Lexington, MA (US)
Filed by MC10, Inc., Cambridge, MA (US)
Filed on Mar. 12, 2015, as Appl. No. 14/656,046.
Claims priority of provisional application 61/952,076, filed on Mar. 12, 2014.
Claims priority of provisional application 61/952,082, filed on Mar. 12, 2014.
Prior Publication US 2015/0260713 A1, Sep. 17, 2015
Int. Cl. B01L 3/00 (2006.01); G01N 21/00 (2006.01); G01N 21/01 (2006.01); G01N 21/27 (2006.01); G01N 35/00 (2006.01); G01N 21/77 (2006.01)
CPC G01N 21/272 (2013.01) [B01L 3/5055 (2013.01); B01L 3/502715 (2013.01); B01L 2200/025 (2013.01); B01L 2300/023 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01); G01N 35/00871 (2013.01); G01N 2021/7783 (2013.01); G01N 2035/00881 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A measurement device comprising:
a diagnostic substrate comprising
(a) a sample receiver to receive a sample, wherein the sample receiver is at least partially formed in or disposed on the diagnostic substrate;
(b) a fluidic channel connected to the sample receiver;
(c) a detection region at least partially formed in or disposed on the diagnostic substrate, wherein the detection region is coupled to the sample receiver by the fluidic channel;
(d) a control region at least partially formed in or disposed on the diagnostic substrate, wherein the control region is coupled to the detection region by the fluidic channel, and
a base substrate comprising
(e) an antenna for near-field communication (NFC) at least partially formed in or disposed on the base substrate;
(f) electronic circuitry connected to the antenna and at least partially formed in or disposed on the base substrate, wherein the electronic circuitry generates data as a function of an output signal from the sample or a derivative thereof;
(g) a first portion comprising a first photodetector and a second photodetector connected to the electronic circuitry and at least partially formed in or disposed on the first portion;
(h) a second portion comprising a first light source and a second light source connected to the electronic circuitry and at least partially formed in or disposed on the second portion, wherein the first portion is folded with respect to the second portion whereby the photodetectors and the light sources are aligned such that light from the first light source passes through the detection region and gets detected by the first photodetector, the light from the second light source passes through the control region and gets detected by the second photodetector, and
(i) a thin-film battery connected to the electronic circuitry and configured to provide power to the at least one of the first photodetector and the second photodetector, and to provide power to at least one of the first light source and the second light source.