US 9,810,144 B2
Process for the crystallisation of a water-soluble compound
Johan Pieter Marinus Sanders, Groningen (NL); Marieke Elisabeth Bruins, Wageningen (NL); and Jeroen Johannes Cornelis Franciscus Van Bon, Bemmel (NL)
Assigned to Wageningen Universiteit, Wageningen (NL)
Filed by Wageningen Universiteit, Wageningen (NL)
Filed on Dec. 16, 2015, as Appl. No. 14/971,431.
Application 14/971,431 is a continuation of application No. 14/006,459, granted, now 9,255,301, previously published as PCT/NL2012/050169, filed on Mar. 19, 2012.
Claims priority of application No. 2006447 (NL), filed on Mar. 22, 2011.
Prior Publication US 2016/0097321 A1, Apr. 7, 2016
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 1/06 (2006.01); C07H 3/04 (2006.01); F02B 43/12 (2006.01); C13B 30/02 (2011.01); C12P 5/02 (2006.01); C12P 7/06 (2006.01); C12P 7/16 (2006.01); B01D 9/00 (2006.01)
CPC F02B 43/12 (2013.01) [B01D 9/0054 (2013.01); C07H 1/06 (2013.01); C07H 3/04 (2013.01); C12P 5/023 (2013.01); C12P 7/06 (2013.01); C12P 7/16 (2013.01); C13B 30/021 (2013.01); C13B 30/022 (2013.01); Y02E 50/17 (2013.01); Y02E 50/343 (2013.01); Y02T 10/32 (2013.01)] 15 Claims
 
1. A process for crystallisation of a water-soluble compound from a solution, comprising:
(a) providing, in a crystallisation vessel, a solution of the water-soluble compound in a mixture of water and a solvent, wherein the water-soluble compound has a lower solubility in the solvent than in water;
(b) passing vapour phase of the mixture through a sorption zone containing a water vapor sorbent to selectively adsorb water from the vapour phase to obtain a vapour phase depleted in water and enriched in the solvent and water-saturated water vapour sorbent;
(c) enriching the mixture in the crystallisation vessel in solvent by (i) recycling at least part of the vapour phase depleted in water and enriched in the solvent to the crystallisation vessel or (ii) withdrawing vapour phase depleted in water from the process and adding solvent from an external source to the crystallisation vessel;
(d) allowing solid crystals of the water-soluble compound to precipitate from the solution in the crystallisation vessel at a crystallisation temperature; and
(e) discharging precipitated solid crystals of the water-soluble compound from the crystallisation vessel and discharging a solution of non-crystallised water-soluble compound in water-solvent mixture from the crystallisation vessel.