US 9,809,853 B2
Calcium-activated chloride channel involved in human sweat formation
Torsten Ertongur-Fauth, Darmstadt (DE); Andreas Hochheimer, Darmstadt (DE); and Michael Krohn, Lorsch (DE)
Assigned to Brain Biotechnology Research and Information Network AG, Zwingenberg (DE)
Appl. No. 14/422,313
Filed by BRAIN Biotechnology Research and Information Network AG, Zwingenberg (DE)
PCT Filed Aug. 14, 2013, PCT No. PCT/EP2013/067044
§ 371(c)(1), (2) Date Feb. 18, 2015,
PCT Pub. No. WO2014/027050, PCT Pub. Date Feb. 20, 2014.
Claims priority of application No. 12180628 (EP), filed on Aug. 16, 2012.
Prior Publication US 2015/0240303 A1, Aug. 27, 2015
Int. Cl. C12P 21/02 (2006.01); C12Q 1/68 (2006.01); C07K 14/705 (2006.01)
CPC C12Q 1/6876 (2013.01) [C07K 14/705 (2013.01); C12Q 2600/106 (2013.01)] 13 Claims
 
1. A vector comprising a nucleic acid molecule encoding a protein capable of forming a calcium-activated chloride channel,
wherein said nucleic acid molecule comprises or consists of
(a) a nucleic acid molecule encoding a protein having the amino acid sequence of SEQ ID NO:1;
(b) a nucleic acid molecule having the DNA sequence of SEQ ID NO:2;
(c) a nucleic acid molecule having the sequence of SEQ ID NO:2, wherein each thymine is replaced by uracil;
(d) a nucleic acid molecule encoding a protein having at least 97% sequence identity to the protein of (a); or
(e) a nucleic acid molecule that is degenerate with respect to the nucleic acid molecule of (b), or (c),
wherein the nucleic acid molecule of (a), (b), (c), (d), or (e) is inserted into the vector such that a translational fusion with another nucleic acid molecule is generated.