US 9,809,831 B2
Monascus strains modified for organic acid production
Alexander Ruud Weusthuis, GD Heelsum (NL); Emil Johan Harald Wolbert, LP Wageningen (NL); Jan Springer, AL Wageningen (NL); John Van Der Oost, HZ Renkum (NL); and Gerrit Eggink, SC Ede (NL)
Assigned to TOTAL RESEARCH & TECHNOLOGY FELUY, Seneffe (Feluy) (BE)
Appl. No. 13/882,460
Filed by Alexander Ruud Weusthuis, GD Heelsum (NL); Emil Johan Harald Wolbert, LP Wageningen (NL); Jan Springer, AL Wageningen (NL); John Van Der Oost, HZ Renkum (NL); and Gerrit Eggink, SC Ede (NL)
PCT Filed Oct. 28, 2011, PCT No. PCT/EP2011/068968
§ 371(c)(1), (2), (4) Date Jul. 29, 2013,
PCT Pub. No. WO2012/055996, PCT Pub. Date May 3, 2012.
Claims priority of provisional application 61/407,747, filed on Oct. 28, 2010.
Claims priority of application No. 10290583 (EP), filed on Oct. 28, 2010.
Prior Publication US 2013/0303802 A1, Nov. 14, 2013
This patent is subject to a terminal disclaimer.
Int. Cl. C12P 7/56 (2006.01); C12P 7/40 (2006.01); C12N 9/04 (2006.01); C12R 1/645 (2006.01); C12P 7/62 (2006.01); C12P 7/46 (2006.01)
CPC C12P 7/40 (2013.01) [C12N 9/0006 (2013.01); C12P 7/46 (2013.01); C12P 7/56 (2013.01); C12P 7/625 (2013.01); C12R 1/645 (2013.01); C12Y 101/01027 (2013.01)] 13 Claims
 
1. A genetically modified or recombinant micro-organism of the genus Monascus, wherein the micro-organism is tolerant to organic acid at a concentration of at least 50 g/L and a pH of less than 5.0, and wherein the micro-organism has been genetically modified for increased production of a lactic acid by the introduction of an exogenous lactate dehydrogenase (LDH) gene.