US 9,809,810 B2
Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells
Vish Subramaniam, Westerville, OH (US); Joseph West, Richwood, OH (US); Emily Alkandry, Columbus, OH (US); Mohd Nasser, Columbus, OH (US); Dinesh Ahirwar, Columbus, OH (US); and Ramesh Ganju, Dublin, OH (US)
Assigned to Ohio State Innovation Foundation, Columbus, OH (US)
Appl. No. 14/765,993
Filed by Ohio State Innovation Foundation, Columbus, OH (US)
PCT Filed Feb. 5, 2014, PCT No. PCT/US2014/014779
§ 371(c)(1), (2) Date Aug. 5, 2015,
PCT Pub. No. WO2014/123947, PCT Pub. Date Aug. 14, 2014.
Claims priority of provisional application 61/760,987, filed on Feb. 5, 2013.
Prior Publication US 2015/0376598 A1, Dec. 31, 2015
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 13/00 (2006.01); A61N 2/00 (2006.01); A61N 2/02 (2006.01)
CPC C12N 13/00 (2013.01) [A61N 2/004 (2013.01); A61N 2/02 (2013.01)] 10 Claims
OG exemplary drawing
1. A method for controlling cell migration comprising the steps of:
providing an electromagnetic coil having a first end and a second end;
connecting the electromagnetic coil to a function generator;
applying a time-varying voltage waveform to the electromagnetic coil;
inducing a time-varying electric field around the electromagnetic coil;
placing the electromagnetic coil adjacent to, and without contacting, the location of cancer cells;
directing the induced electric field along an axis of migration of the cancer cells;
orientating the placement of the electromagnetic coil to control the direction of the induced electric field; and
reducing the migration of the cancer cells using the induced electric field.