US 9,809,801 B2
Anti-mycobacterial vaccines
Elodie Anne Françoise Belnoue, Genève (CH); Stéphanie Gabrielle Darbre Abdelrahman, Lausanne (CH); Arun Thomas Kamath, Lyons (AU); Paul Lambert, Versoix (CH); Claire-Anne Siegrist-Julliard, Troinex (CH); and Daniel David Pinschewer, Vésenaz (CH)
Assigned to Université de Genève, Genève (CH)
Appl. No. 14/775,484
Filed by Université de Genève, Genève (CH)
PCT Filed Mar. 14, 2014, PCT No. PCT/EP2014/055144
§ 371(c)(1), (2) Date Sep. 11, 2015,
PCT Pub. No. WO2014/140301, PCT Pub. Date Sep. 18, 2014.
Claims priority of provisional application 61/793,522, filed on Mar. 15, 2013.
Prior Publication US 2016/0024476 A1, Jan. 28, 2016
Int. Cl. A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61K 39/12 (2006.01); A61K 39/04 (2006.01); C07H 21/02 (2006.01); C12N 7/00 (2006.01); A61K 35/76 (2015.01)
CPC C12N 7/00 (2013.01) [A61K 35/76 (2013.01); A61K 39/02 (2013.01); A61K 39/04 (2013.01); C12N 2760/10021 (2013.01); C12N 2760/10031 (2013.01); C12N 2760/18511 (2013.01); C12N 2760/18534 (2013.01); C12N 2810/85 (2013.01)] 3 Claims
OG exemplary drawing
 
1. An infectious, replication-deficient arenavirus particle comprising a nucleotide sequence encoding a mycobacterial antigen, wherein the mycobacterial antigen is a fusion protein comprising Ag85B or an antigenic fragment thereof and TB10.4 or an antigenic fragment thereof wherein the mycobacterial antigen is fused to a signal peptide of a tissue plasminogen activator, and wherein the signal peptide of a tissue plasminogen activator comprises the amino acid sequence of SEQ ID NO:7.