US 9,809,653 B2
Anti-LAMP1 antibodies and antibody drug conjugates, and uses thereof
Yves Baudat, Paris (FR); Francis Blanche, Paris (FR); Béatrice Cameron, Paris (FR); Tarik Dabdoubi, Le Coudray Montceaux (FR); Anne-Marie LeFebvre, Le Plessis Pâté (FR); Magali Mathieu, Choisy le Roi (FR); Ana Merino-Trigo, Paris (FR); and Manoel Nunes, Paris (FR)
Assigned to SANOFI, Paris (FR)
Filed by SANOFI, Paris (FR)
Filed on Jun. 26, 2015, as Appl. No. 14/751,598.
Application 14/751,598 is a continuation of application No. PCT/EP2013/078017, filed on Dec. 26, 2013.
Claims priority of application No. 12306691 (EP), filed on Dec. 27, 2012; and application No. 12306694 (EP), filed on Dec. 27, 2012.
Prior Publication US 2016/0280793 A1, Sep. 29, 2016
Int. Cl. A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 47/48 (2006.01); G01N 33/574 (2006.01); C07K 16/30 (2006.01); C12Q 1/68 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/2896 (2013.01) [A61K 47/48384 (2013.01); A61K 47/48561 (2013.01); A61K 47/48569 (2013.01); A61K 47/48584 (2013.01); A61K 47/48592 (2013.01); A61K 47/48615 (2013.01); C07K 16/30 (2013.01); C07K 16/3023 (2013.01); C07K 16/3046 (2013.01); C07K 16/3069 (2013.01); C12Q 1/6886 (2013.01); G01N 33/574 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/41 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01)] 17 Claims
 
1. An immunoconjugate comprising a) an antibody or antigen binding fragment thereof wherein said antibody or antigen binding fragment thereof binds to a first lumenal domain of human LAMP1 protein and
b) at least one growth inhibitory agent, wherein the at least one growth inhibitory agent is linked to the antibody or antigen binding fragment thereof.