US 9,809,649 B2
Cachexia treatment
John Simard, Austin, TX (US)
Assigned to XBIOTECH, INC., Vancouver (CA)
Filed by XBiotech, Inc., Vancouver (CA)
Filed on Sep. 21, 2012, as Appl. No. 13/624,004.
Claims priority of provisional application 61/538,309, filed on Sep. 23, 2011.
Prior Publication US 2013/0078258 A1, Mar. 28, 2013
Int. Cl. C07K 16/24 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/245 (2013.01) [A61K 39/395 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01)] 14 Claims
 
1. A method of treating cachexia in a human subject suffering from cachexia, the method comprising the step of administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an amount of an anti-interlukin-1 alpha (IL-1α ) antibody (Ab) effective to increase the subject's lean body mass, body weight, appetite, or muscle mass; wherein the subject's lean body mass, body weight, appetite, or muscle mass is increased, thereby treating cachexia.