US 9,809,646 B2
Methods for treating thrombosis using chimeric and humanized anti-histone antibodies
Chien-Hsing Chang, Downingtown, PA (US); Hans J. Hansen, Picayune, MS (US); and David M. Goldenberg, Mendham, NJ (US)
Filed by Immunomedics, Inc., Morris Plains, NJ (US)
Filed on Apr. 14, 2017, as Appl. No. 15/487,747.
Application 15/487,747 is a division of application No. 15/005,596, filed on Jan. 25, 2016, granted, now 9,657,093.
Application 15/005,596 is a division of application No. 14/620,315, filed on Feb. 12, 2015, granted, now 9,278,129, issued on Mar. 8, 2016.
Application 14/620,315 is a division of application No. 14/180,646, filed on Feb. 14, 2014, granted, now 8,987,421, issued on Mar. 24, 2015.
Claims priority of provisional application 61/765,150, filed on Feb. 15, 2013.
Prior Publication US 2017/0218059 A1, Aug. 3, 2017
Int. Cl. C07K 16/18 (2006.01); A61K 39/395 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); A61K 31/573 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/18 (2013.01) [A61K 31/573 (2013.01); A61K 39/3955 (2013.01); C07K 16/24 (2013.01); C07K 16/248 (2013.01); C07K 16/2833 (2013.01); C07K 16/2851 (2013.01); C07K 16/2887 (2013.01); A61K 2039/507 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 26 Claims
 
1. A method of treating thrombosis, comprising administering to a subject with thrombosis a chimeric or humanized anti-histone H4 antibody or antigen-binding fragment thereof, comprising the heavy chain complementarity-determining region (CDR) sequences CDR1 (DDYLH, SEQ ID NO:90), CDR2 (WIGWIDPENGDTEYASKFQG, SEQ ID NO:91) and CDR3 (PLVHLRTFAY, SEQ ID NO:92) and the light chain CDR sequences CDR1 (RASESVDSYDNSLH, SEQ ID NO:93), CDR2 (LASNLES, SEQ ID NO:94) and CDR3 (QQNNEDPWT, SEQ ID NO:95).