US 9,809,644 B2
Influenza hemagglutinin antibodies, compositions and related methods
Vidadi Yusibov, Havertown, PA (US); Vadim Mett, Elma, NY (US); Jessica Chichester, Glen Mills, PA (US); and Lauren Goldschmidt, Drexel Hill, PA (US)
Assigned to iBio Inc., New York, NY (US)
Filed by iBio Inc., New York, NY (US)
Filed on Jul. 21, 2014, as Appl. No. 14/336,071.
Application 14/336,071 is a continuation of application No. 13/498,946, granted, now 8,784,819, previously published as PCT/US2010/050693, filed on Sep. 29, 2010.
Claims priority of provisional application 61/246,958, filed on Sep. 29, 2009.
Prior Publication US 2014/0331366 A1, Nov. 6, 2014
Int. Cl. A61K 39/42 (2006.01); C12N 7/00 (2006.01); C07H 21/02 (2006.01); C07K 16/10 (2006.01); C12N 15/82 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/1018 (2013.01) [C12N 15/8258 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A recombinant nucleic acid comprising a nucleotide sequence encoding an antibody light chain or an antibody heavy chain,
wherein the antibody light chain comprises:
(a) the light chain variable region amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79 or the light chain variable region amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79 with variants such that it is at least 95% identical to the amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79, or
(b) the light chain variable region amino acid sequence set forth in amino acids 1-96 of SEQ ID NO:81 or the light chain variable region amino acid sequence set forth in amino acids 1-96 of SEQ ID NO: 81 with variants such that it is at least 98% identical to the amino acid sequence set forth in amino acids 1-96 of SEQ ID NO:81; and
wherein the antibody heavy chain comprises:
(c) the heavy chain variable region amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78 or the heavy chain variable region amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78 with variants such that it is at least 95% identical to the amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78, or
(d) the heavy chain variable region amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80 or the heavy chain variable region amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80 with variants such that it is at least 90% identical to the amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80.