US 9,809,643 B2
Identification of antibodies specific for at least two different lyssaviruses
Todd G. Smith, Decatur, GA (US); and Xianfu Wu, Atlanta, GA (US)
Assigned to The United States of America as represented by the Secretary of the Department of Health and Human Services, Washington, DC (US)
Filed by The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention, Washington, DC (US)
Filed on Jul. 30, 2015, as Appl. No. 14/813,427.
Application 14/813,427 is a division of application No. 13/879,782, granted, now 9,115,187, previously published as PCT/US2011/056738, filed on Oct. 18, 2011.
Claims priority of provisional application 61/394,651, filed on Oct. 19, 2010.
Prior Publication US 2016/0024185 A1, Jan. 28, 2016
Int. Cl. C07K 16/10 (2006.01); G01N 33/569 (2006.01); C12Q 1/00 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/10 (2013.01) [G01N 33/56983 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/52 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C12N 2760/20145 (2013.01); C12N 2810/6081 (2013.01); C12Q 1/00 (2013.01); G01N 2333/145 (2013.01); G01N 2500/10 (2013.01)] 12 Claims
 
1. An isolated monoclonal antibody, or antigen-binding fragment thereof, that specifically binds at least two different lyssaviruses or that specifically binds glycoprotein from at least two different lyssaviruses, wherein the antibody or antigen-binding fragment thereof comprises a variable heavy (VH) domain complementarity determining region 1 (CDR1), CDR2 and CDR3, and wherein the CDR1, CDR2 and CDR3 are encoded by the CDR1, CDR2 and CDR3 nucleotide sequences of SEQ ID NO: 44.