US 9,809,640 B2
ApoE peptide dimers and uses thereof
Michael P. Vitek, Research Triangle Park, NC (US); and Dale J. Christensen, Research Triangle Park, NC (US)
Assigned to Cognosci, Inc., Durham, NC (US)
Filed by COGNOSCI, INC., Research Triangle Park, NC (US)
Filed on Oct. 6, 2015, as Appl. No. 14/875,919.
Application 14/875,919 is a continuation of application No. 13/520,623, abandoned, previously published as PCT/US2011/020393, filed on Jan. 6, 2011.
Claims priority of provisional application 61/292,668, filed on Jan. 6, 2010.
Prior Publication US 2016/0096877 A1, Apr. 7, 2016
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/775 (2006.01); A61K 38/17 (2006.01); A61K 47/48 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/775 (2013.01) [A61K 38/1709 (2013.01); A61K 47/48246 (2013.01); A61K 38/00 (2013.01)] 14 Claims
1. A peptide dimer comprising a first ApoE peptide and a second ApoE peptide, wherein each of said first and second ApoE peptides is no more than 20 amino acids in length and comprises a sequence selected from the group consisting of CLRVRLASHLRKLRKRLL (SEQ ID NO: 15), CAS(Aib)LRKL(Aib)KRLL (SEQ ID NO: 16), CLRVRLAS(Aib)LKRLRK(Nitro-Arg)LL (SEQ ID NO: 17), and CLRVRLAS(Aib)LRKLR(K-Ac)RLL (SEQ ID NO: 18), wherein the first and second ApoE peptides are covalently cross-linked through the cysteine residue at each amino terminus via a bismaleimide linker.