US 9,809,636 B2
Methods for increasing red blood cell levels comprising administering BMP9
Ravindra Kumar, Acton, MA (US); Naga Venkata Sai Rajasekhar Suragani, Norwood, MA (US); and John Knopf, Carlisle, MA (US)
Assigned to ACCELERON PHARMA INC., Cambridge, MA (US)
Filed by Acceleron Pharma, Inc., Cambridge, MA (US)
Filed on Mar. 14, 2013, as Appl. No. 13/827,477.
Claims priority of provisional application 61/621,154, filed on Apr. 6, 2012.
Prior Publication US 2013/0281371 A1, Oct. 24, 2013
Int. Cl. C07K 14/51 (2006.01)
CPC C07K 14/51 (2013.01) [C07K 2319/02 (2013.01)] 17 Claims
1. A method for increasing red blood cell levels or treating anemia in a patient, the method comprising administering to a patient in need thereof a BMP9polypeptide comprising an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO: 3, wherein the BMP9 polypeptide binds to ALK1 and increases red blood cell levels when administered to the patient.