US 9,809,635 B2
BMP-2 peptides and methods of use
Xiaofei Qin, Virginia Beach, VA (US); Silvia Chen, Virginia Beach, VA (US); Jingsong Chen, Virginia Beach, VA (US); and James A. Clagett, Virginia Beach, VA (US)
Assigned to LifeNet Health, Virginia Beach, VA (US)
Appl. No. 13/636,016
Filed by Xiaofei Qin, Virginia Beach, VA (US); Silvia Chen, Virginia Beach, VA (US); Jingsong Chen, Virginia Beach, VA (US); and James A. Clagett, Virginia Beach, VA (US)
PCT Filed Mar. 21, 2011, PCT No. PCT/US2011/029258
§ 371(c)(1), (2), (4) Date Dec. 10, 2012,
PCT Pub. No. WO2011/116391, PCT Pub. Date Sep. 22, 2011.
Claims priority of provisional application 61/315,454, filed on Mar. 19, 2010.
Prior Publication US 2013/0090290 A1, Apr. 11, 2013
Int. Cl. A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/43 (2006.01); A61K 38/48 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 14/435 (2006.01); C07K 14/475 (2006.01); C07K 14/51 (2006.01); C12N 9/00 (2006.01); C12N 9/48 (2006.01); C12N 5/077 (2010.01)
CPC C07K 14/51 (2013.01) [C12N 5/0654 (2013.01); C12N 2501/155 (2013.01); C12N 2506/1323 (2013.01)] 20 Claims
 
1. A composition comprising
(a) a peptide consisting of the amino acid sequence of SEQ ID NO: 2, wherein the peptide has osteoinductive activity or chondroinductive activity, and
(b) collagenase, wherein the molar ratio of the peptide to collagenase is between 1:100 and 100:1.