US 9,809,629 B2
Hypoallergenic variants of Phl p 5, the major allergen from Phleum pratense
Giovanni Mistrello, Milan (IT); Stefania Zanotta, Milan (IT); and Daniela Roncarolo, Milan (IT)
Assigned to LOFARMA S.P.A., Milan (IT)
Appl. No. 14/366,338
Filed by LOFARMA S.P.A., Milan (IT)
PCT Filed Dec. 18, 2012, PCT No. PCT/EP2012/075982
§ 371(c)(1), (2) Date Jun. 18, 2014,
PCT Pub. No. WO2013/092605, PCT Pub. Date Jun. 27, 2013.
Claims priority of application No. MI2011A2301 (IT), filed on Dec. 19, 2011.
Prior Publication US 2014/0328881 A1, Nov. 6, 2014
Int. Cl. C07K 14/415 (2006.01); A61K 39/36 (2006.01); A61K 36/899 (2006.01)
CPC C07K 14/415 (2013.01) [A61K 36/899 (2013.01); A61K 39/36 (2013.01); C07K 2319/00 (2013.01)] 14 Claims
 
1. A hybrid protein containing a hypoallergenic sequence variant of the Phl p 5 major allergen from Phleum pratense pollen consisting of SEQ ID NO:2 and a hypoallergenic sequence variant of the major allergen Phl p 1 from Phleum pratense pollen consisting of SEQ ID NO: 6.