US 9,809,627 B2
Cyclized transthyretin peptide and methods of use therefor
Regina M. Murphy, Madison, WI (US); Patricia Y. Cho, Madison, WI (US); Jeffrey A. Johnson, Verona, WI (US); and Xiaomeng Lu, Madison, WI (US)
Assigned to Wisconsin Alumni Research Foundation, Madison, WI (US)
Filed by Wisconsin Alumni Research Foundation, Madison, WI (US)
Filed on Oct. 15, 2015, as Appl. No. 14/884,205.
Claims priority of provisional application 62/064,279, filed on Oct. 15, 2014.
Prior Publication US 2016/0108093 A1, Apr. 21, 2016
Int. Cl. C07K 14/00 (2006.01); C07K 7/64 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/001 (2013.01) [C07K 7/64 (2013.01); A61K 38/00 (2013.01)] 25 Claims
 
1. A cyclized peptide comprising the sequence SKVVTPXRYXIAALLXPYXXXQ (SEQ ID NO: 2), wherein X represents the same amino acid or a conservative amino acid substitution of the corresponding position in the sequence SKVVTPPRYTIAALLSPYSYSQ (SEQ ID NO: 1).