US 9,809,620 B2
Prion disease-specific epitopes and methods of use thereof
Kristen Marciniuk, Saskatoon (CA); Ryan Taschuk, Saskatoon (CA); Scott Napper, Saskatoon (CA); Andrew Potter, Saskatoon (CA); and Neil Cashman, Saskatoon (CA)
Assigned to University of Saskatchewan, Saskatchewan (CA)
Filed by University of Saskatchewan, Saskatoon (CA)
Filed on Apr. 29, 2014, as Appl. No. 14/265,136.
Claims priority of provisional application 61/817,827, filed on Apr. 30, 2013.
Claims priority of provisional application 61/899,989, filed on Nov. 5, 2013.
Prior Publication US 2015/0004185 A1, Jan. 1, 2015
Int. Cl. A61K 39/00 (2006.01); C07K 14/47 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 16/28 (2006.01); C07K 16/18 (2006.01); C07K 14/00 (2006.01); C07K 16/44 (2006.01); G01N 33/68 (2006.01); C07K 14/285 (2006.01)
CPC C07K 7/06 (2013.01) [A61K 39/0007 (2013.01); C07K 14/001 (2013.01); C07K 14/285 (2013.01); C07K 14/47 (2013.01); C07K 16/18 (2013.01); C07K 16/44 (2013.01); G01N 33/6854 (2013.01); G01N 33/6896 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/6037 (2013.01); C07K 2317/34 (2013.01); C07K 2319/00 (2013.01); C07K 2319/40 (2013.01); C12N 2760/20134 (2013.01); G01N 2333/001 (2013.01); G01N 2800/24 (2013.01); G01N 2800/2828 (2013.01)] 17 Claims
 
1. A fusion peptide comprising three or more repeats of an immunogenic peptide, wherein the immunogenic peptide is selected from (a) a peptide comprising the sequence GYMLGSAMSRP (SEQ ID NO:17); (b) a peptide comprising the sequence VDQYSNQNNF (SEQ ID NO:19); or (c) a peptide comprising a sequence corresponding to GYMLGSAMSRP (SEQ ID NO:17) or VDQYSNQNNF (SEQ ID NO:19) from another non-bovine mammalian species,
wherein one or more of the repeats is in an inverted orientation.