US 9,809,609 B2
Water-soluble benzoazepine compound and its pharmaceutical composition
Makoto Komatsu, Tokushima (JP); Fumitaka Goto, Tokushima (JP); Yasuhiro Menjo, Tokushima (JP); Keigo Yamada, Tokushima (JP); Takakuni Matsuda, Tokushima (JP); and Yusuke Kato, Tokushima (JP)
Assigned to OTSUKA PHARMACEUTICAL CO., LTD., Tokyo (JP)
Filed by Makoto Komatsu, Tokushima (JP); Fumitaka Goto, Tokushima (JP); Yasuhiro Menjo, Tokushima (JP); Keigo Yamada, Tokushima (JP); Takakuni Matsuda, Tokushima (JP); and Yusuke Kato, Tokushima (JP)
Filed on May 1, 2012, as Appl. No. 13/461,642.
Application 13/461,642 is a continuation of application No. 12/980,266, filed on Dec. 28, 2010, abandoned.
Application 12/980,266 is a continuation of application No. 12/159,027, abandoned, previously published as PCT/JP2006/326311, filed on Dec. 22, 2006.
Claims priority of application No. 2005-375457 (JP), filed on Dec. 27, 2005.
Prior Publication US 2012/0277188 A1, Nov. 1, 2012
This patent is subject to a terminal disclaimer.
Int. Cl. C07F 9/553 (2006.01); A61K 31/675 (2006.01); A61P 9/08 (2006.01); A61P 9/12 (2006.01); A61P 7/02 (2006.01); A61P 7/00 (2006.01)
CPC C07F 9/5535 (2013.01) [Y02P 20/55 (2015.11)] 13 Claims
 
1. A benzoazepine compound represented by formula (1)

OG Complex Work Unit Drawing
or a salt thereof,
wherein R represents a hydrogen atom, a hydroxy group optionally protected with a protecting group, a mercapto group optionally protected with a protecting group, or an amino group optionally protected with one or two protecting groups; R1 represents a hydrogen atom or a hydroxy-protecting group; and X represents an oxygen atom or a sulfur atom.