US 9,809,563 B2
Maleic acid salt of anti-prion compound, method for producing the same and pharmaceutical composition of the same
Kazuo Kuwata, Gifu (JP)
Assigned to GIFU University, Gifu (JP)
Appl. No. 15/114,494
Filed by GIFU University, Gifu (JP)
PCT Filed Feb. 3, 2015, PCT No. PCT/JP2015/052982
§ 371(c)(1), (2) Date Sep. 8, 2016,
PCT Pub. No. WO2015/119111, PCT Pub. Date Aug. 13, 2015.
Claims priority of application No. 2014-023838 (JP), filed on Feb. 10, 2014.
Prior Publication US 2016/0368885 A1, Dec. 22, 2016
Int. Cl. C07D 295/15 (2006.01); C07C 57/145 (2006.01)
CPC C07D 295/15 (2013.01) [C07C 57/145 (2013.01)] 4 Claims
OG exemplary drawing
 
1. A method for, ameliorating or treating a PrP prion disease, the method comprising administering the maleic acid salt of a compound represented by formula (1)

OG Complex Work Unit Drawing
wherein the crystalline form has an X-ray diffraction pattern comprising characteristic peaks at:
   
    2 Theta (Degrees)  
   
     6.6 ± 0.1  
    10.6 ± 0.1  
    13.1 ± 0.1  
    14.2 ± 0.1  
     27.3 ± 0.1.