US 9,809,556 B2
Treatment of amyotrophic lateral sclerosis
Richard B. Silverman, Winnetka, IL (US); and Yinan Zhang, Lexington, KY (US)
Assigned to Northwestern University, Evanston, IL (US)
Filed by Northwestern University, Evanston, IL (US)
Filed on Sep. 28, 2015, as Appl. No. 14/867,624.
Application 14/867,624 is a continuation of application No. 14/103,728, filed on Dec. 11, 2013, granted, now 9,145,424.
Application 14/103,728 is a continuation in part of application No. 13/129,854, previously published as PCT/US2009/006237, filed on Nov. 20, 2009.
Claims priority of provisional application 61/735,867, filed on Dec. 11, 2012.
Claims priority of provisional application 61/116,571, filed on Nov. 20, 2008.
Prior Publication US 2016/0016911 A1, Jan. 21, 2016
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 231/20 (2006.01); C07D 231/18 (2006.01); C07D 498/04 (2006.01); C07D 403/06 (2006.01); C07D 401/06 (2006.01); C07D 471/04 (2006.01)
CPC C07D 231/18 (2013.01) [C07D 231/20 (2013.01); C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01)] 19 Claims
 
1. A compound selected from compounds of a formula

OG Complex Work Unit Drawing
wherein each of R1-R4 is independently selected from H, alkyl, cycloalkyl, alkylsulfonyl, alkylcarbonyl, aryl, arylalkyl, alkenylalkyl and alkynylalkyl moieties; each of R′1-R′4 is independently selected from H, alkyl, amino, alkylamino, alkylsulfonyl, alkylcarbonyl, alkoxy, alkoxycarbonyl, cyano, and halo moieties; m is an integer selected from 0-3, and n is an integer selected from 1-3; and salts, tautomers and combinations thereof.