US 9,809,551 B2
Solid forms of Ivacaftor and processes for the preparation thereof
Padiyath Mohammed Akbarali, Bangalore (IN); Kintali Venkata Ramana, Bangalore (IN); Heggadde Nanjunda Bhatta Shreenivasa Murthy, Bangalore (IN); Sankaran Suresh Kumar, Tamil Nadu (IN); Ekkaluru Vijaya Bhaskar, Bangalore (IN); Nechipadappu Sunil Kumar, Bangalore (IN); and Karad Manjunath, Bangalore (IN)
Assigned to Apotex Inc., Toronto, Ontario (CA)
Appl. No. 15/36,137
Filed by Apotex Inc., Toronto (CA)
PCT Filed Nov. 13, 2014, PCT No. PCT/CA2014/000828
§ 371(c)(1), (2) Date May 12, 2016,
PCT Pub. No. WO2015/070336, PCT Pub. Date May 21, 2015.
Claims priority of application No. 5143/CHE/2013 (IN), filed on Nov. 13, 2013.
Prior Publication US 2016/0280654 A1, Sep. 29, 2016
Int. Cl. C07D 215/56 (2006.01); A61K 31/47 (2006.01); A61P 11/00 (2006.01)
CPC C07D 215/56 (2013.01) [A61K 31/47 (2013.01); C07B 2200/13 (2013.01)] 9 Claims
 
1. A polymorphic form APO-I of Ivacaftor having a powder x-ray diffractogram comprising peaks, in terms of 2-theta degrees, at: 4.3±0.2, 4.8±0.2, 9.5±0.2, 13.0±0.2, 20.0±0.2 and 28.8±0.2.