US 9,809,546 B2
Process for producing diamine derivative
Tzu-Chiang Lu, New Taipei (TW); Chien-Yi Chen, New Taipei (TW); Ching-Shuen Cheng, New Taipei (TW); and Chin-Cheng Mai, New Taipei (TW)
Assigned to Chungwha Chemical Synthesis & Biotech Co., Ltd., New Taipei (TW)
Filed by CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO. LTD., New Taipei (TW)
Filed on May 12, 2016, as Appl. No. 15/153,352.
Claims priority of application No. 105107737 A (TW), filed on Mar. 14, 2016.
Prior Publication US 2017/0260138 A1, Sep. 14, 2017
Int. Cl. C07D 213/75 (2006.01)
CPC C07D 213/75 (2013.01) 9 Claims
 
1. A process for producing a compound of formula (D):

OG Complex Work Unit Drawing
comprising the following steps:
step 1: placing a HCl salt of formula (C) into an organic solvent containing dimethyl sulfoxide or dimethylformamide and treating with a di(C1-C4 alkyl)amines:

OG Complex Work Unit Drawing
step 2: adding a compound of formula (A) or a salt or a salt hydrate thereof into the mixture of step 1:

OG Complex Work Unit Drawing
and
step 3: crystallizing the mixture processed in step 2.