US 9,809,514 B2
Method for producing (bromomethyl)cyclopropane and (bromomethyl)cyclobutane
Olivier Guerret, Pern (FR)
Assigned to MELCHIOR MATERIAL AND LIFE SCIENCE FRANCE, Lacq (FR)
Appl. No. 15/109,925
Filed by MELCHIOR MATERIAL AND LIFE SCIENCE FRANCE, Lacq (FR)
PCT Filed Dec. 1, 2014, PCT No. PCT/EP2014/076131
§ 371(c)(1), (2) Date Jul. 6, 2016,
PCT Pub. No. WO2015/101452, PCT Pub. Date Jul. 9, 2015.
Claims priority of application No. 14 50060 (FR), filed on Jan. 6, 2014.
Prior Publication US 2016/0355452 A1, Dec. 8, 2016
Int. Cl. C07C 17/16 (2006.01); C07C 22/00 (2006.01)
CPC C07C 17/16 (2013.01) [C07C 2101/02 (2013.01); C07C 2101/04 (2013.01)] 16 Claims
 
1. A method for preparing a compound (A) of the following formula:

OG Complex Work Unit Drawing
in which R is a cyclobutane or cyclopropane group, comprising the following steps:
a) solubilizing a triarylphosphite in a polar aprotic solvent,
b) adding a bromine compound at a temperature of less than 15° C.,
c) lowering the temperature to less than 0° C. after completion of the reaction of the bromine with the triarylphosphite,
d) adding cyclobutylmethanol or cyclopropylmethanol at a temperature of less than 0° C.,
e) recovering the compound (A).