US 9,809,016 B2
Bonding process
Ajay D. Padsalgikar, Plymouth, MN (US)
Assigned to Aortech International plc, Glasgow (GB)
Filed by Aortech International plc, Glasgow (GB)
Filed on Jun. 28, 2016, as Appl. No. 15/195,790.
Application 15/195,790 is a continuation of application No. 14/957,598, filed on Dec. 3, 2015, granted, now 9,421,737.
Application 14/957,598 is a continuation of application No. 14/113,640, granted, now 9,216,558, previously published as PCT/US2012/035241, filed on Apr. 26, 2012.
Claims priority of provisional application 61/479,038, filed on Apr. 26, 2011.
Prior Publication US 2017/0028694 A1, Feb. 2, 2017
Int. Cl. B32B 37/06 (2006.01); B29C 59/08 (2006.01); C08G 77/16 (2006.01); B32B 27/08 (2006.01); B32B 27/28 (2006.01); B32B 27/40 (2006.01); C08J 7/04 (2006.01); C09J 5/02 (2006.01); C08J 5/12 (2006.01); B32B 7/10 (2006.01); B32B 7/12 (2006.01); C09J 175/04 (2006.01); B29C 65/48 (2006.01); B29C 65/00 (2006.01)
CPC B32B 37/06 (2013.01) [B29C 59/08 (2013.01); B32B 7/10 (2013.01); B32B 7/12 (2013.01); B32B 27/08 (2013.01); B32B 27/28 (2013.01); B32B 27/40 (2013.01); C08G 77/16 (2013.01); C08J 5/121 (2013.01); C08J 7/04 (2013.01); C09J 5/02 (2013.01); C09J 175/04 (2013.01); B29C 65/4895 (2013.01); B29C 66/028 (2013.01); B29C 66/71 (2013.01); B32B 2535/00 (2013.01); C08J 2375/04 (2013.01); C08J 2383/04 (2013.01); C09J 2475/003 (2013.01); C09J 2475/006 (2013.01); C09J 2483/006 (2013.01); C09J 2483/008 (2013.01); Y10T 428/31598 (2015.04)] 12 Claims
 
1. A process for manufacturing a long term implantable medical device comprising:
providing a substrate for the device of, or having a section coated with, a silicone or silicone based material;
flame treating a surface of the silicone or silicone based material; and
bonding a polyurethane or polyurethane urea to the flame treated surface of the silicone or silicone based material,
the polyurethane or polyurethane urea being selected from biostable polyurethanes and polyurethane ureas comprising soft segments and hard segments, the soft segments having a number average molecular weight of about 500-6000 and being formed from a polysiloxane diol or diamine of the formula (III)

OG Complex Work Unit Drawing
in which
A and A′ are OH or NHR wherein R is H or C1-6 alkyl;
R11, R12, R13 and R14 are independently selected from hydrogen or C1-6 alkyl;
R15 and R16 are the same or different and are selected from propylene, butylene, pentylene, hexylene, ethoxypropyl, propoxypropyl and butoxypropyl;
p is an integer of 1 or greater; and
a polyether diol or diamine represented by the formula (I)
A-[(CH2)m—X]nA′  (I)
in which
A is OH or NHR, X is O or NR and A′ is H wherein R is H or C1-4 alkyl;
m is an integer of 4 to 18; and
n is an integer of 2 to 50; and, optionally,
a poly(alkylene) carbonate (II);
a copoly[ether carbonate] macrodiol, formed by copolymerizing (I) and (II) and/or a silicon-containing poly(alkylene) carbonate (IV) formed by copolymerizing compound (III) and compound (II); and
the hard segment being formed from a(C1-C12) alkane diol or a (C1-C12) alkane diamine and a diisocyanate.