US 9,808,803 B2
Systems and methods for particle focusing in microchannels
Mehmet Toner, Charlestown, MA (US); Dino DiCarlo, Los Angeles, CA (US); Jon F. Edd, Arlington, MA (US); and Daniel Irimia, Charlestown, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Filed by The General Hospital Corporation, Boston, MA (US)
Filed on May 23, 2016, as Appl. No. 15/162,196.
Application 13/619,309 is a division of application No. 13/480,862, filed on May 25, 2012, granted, now 8,784,012, issued on Jul. 22, 2014.
Application 13/480,862 is a division of application No. 12/103,885, filed on Apr. 16, 2008, granted, now 8,186,913, issued on May 29, 2012.
Application 15/162,196 is a continuation of application No. 14/336,889, filed on Jul. 21, 2014, granted, now 9,347,595.
Application 14/336,889 is a continuation of application No. 13/619,309, filed on Sep. 14, 2012, granted, now 8,807,879, issued on Aug. 19, 2014.
Claims priority of provisional application 60/923,609, filed on Apr. 16, 2007.
Claims priority of provisional application 60/923,837, filed on Apr. 17, 2007.
Claims priority of provisional application 60/999,131, filed on Oct. 16, 2007.
Prior Publication US 2017/0080425 A1, Mar. 23, 2017
Int. Cl. B65G 53/00 (2006.01); B01L 3/00 (2006.01); B01D 21/00 (2006.01); B01D 21/26 (2006.01); B01D 45/04 (2006.01); B01D 45/12 (2006.01); F16L 41/02 (2006.01); F17D 1/00 (2006.01); C12M 1/34 (2006.01); C12M 1/00 (2006.01); C12M 3/06 (2006.01); B33Y 80/00 (2015.01); G01N 15/02 (2006.01); G01N 15/10 (2006.01)
CPC B01L 3/502776 (2013.01) [B01D 21/0087 (2013.01); B01D 21/265 (2013.01); B01D 45/04 (2013.01); B01D 45/12 (2013.01); B01L 3/502746 (2013.01); B01L 3/502761 (2013.01); C12M 23/16 (2013.01); C12M 41/36 (2013.01); C12M 47/04 (2013.01); F16L 41/02 (2013.01); F17D 1/00 (2013.01); G01N 15/10 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0883 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0409 (2013.01); B01L 2400/0433 (2013.01); B01L 2400/0454 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0622 (2013.01); B01L 2400/084 (2013.01); B33Y 80/00 (2014.12); G01N 15/0255 (2013.01); G01N 2015/0288 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1081 (2013.01); Y10T 137/85938 (2015.04); Y10T 137/85978 (2015.04); Y10T 436/117497 (2015.01); Y10T 436/2575 (2015.01)] 6 Claims
OG exemplary drawing
 
1. A system for focusing and ordering particles suspended within a moving fluid into one or more localized stream lines, comprising:
a substrate;
at least one expanding spiral-shaped channel having a rectangular cross-section provided on the substrate, wherein the at least one expanding spiral-shaped channel comprises an inlet at or near an inner end of the expanding spiral-shaped channel and at least two outlets at or near an outer end of the expanding spiral-shaped channel, and wherein a radius of curvature of the spiral-shaped channel increases from the inner end to the outer end; and
a pumping element configured to move the fluid and particles along the at least one expanding spiral-shaped channel in one direction and in a laminar flow;
wherein the fluid, the channel, and the pumping element are configured to cause inertial forces to act on the particles to focus the particles into one or more stream lines and to order the particles with a uniform spacing in the direction of the flow.