US 9,808,641 B2
System and method for non-invasive neuronal stimulation
Ingo Wundrich, Kleinmachnow (DE); and Udo Warschewske, Berlin (DE)
Assigned to EBS TECHNOLOGIES GMBH, Kleinmachnow (DE)
Appl. No. 14/916,011
Filed by EBS TECHNOLOGIES GMBH, Kleinmachnow (DE)
PCT Filed Sep. 5, 2014, PCT No. PCT/EP2014/068945
§ 371(c)(1), (2) Date Mar. 2, 2016,
PCT Pub. No. WO2015/032898, PCT Pub. Date Mar. 12, 2015.
Claims priority of application No. 10 2013 014 875 (DE), filed on Sep. 6, 2013; application No. 10 2014 007 645 (DE), filed on May 23, 2014; and application No. 10 2014 011 867 (DE), filed on Aug. 11, 2014.
Prior Publication US 2016/0199662 A1, Jul. 14, 2016
Int. Cl. A61N 1/00 (2006.01); A61N 2/00 (2006.01); A61N 1/04 (2006.01); A61N 1/36 (2006.01); A61N 2/02 (2006.01); A61N 1/32 (2006.01)
CPC A61N 2/002 (2013.01) [A61N 1/0456 (2013.01); A61N 1/0484 (2013.01); A61N 1/36014 (2013.01); A61N 1/36025 (2013.01); A61N 1/36046 (2013.01); A61N 1/36103 (2013.01); A61N 2/006 (2013.01); A61N 2/02 (2013.01); A61N 1/323 (2013.01)] 44 Claims
 
1. A noninvasive electrical and/or magnetic stimulation method for neuronal stimulation of a patient comprising the steps of:
deriving a measurement signal from at least one electrode in electrical communication with the patient,
generating a stimulation signal,
applying the stimulation signal by means of electrodes, i.e., electrical and/or magnetic stimulation,
determining a biomarker from the measurement signal, and
varying the stimulation signal in dependence on the biomarker,
wherein the biomarker is functionally dependent on the measurement signal, and wherein the method further comprises the step of:
determining the functional dependence of the biomarker by machine learning using training data from test subjects.