US 9,808,616 B2
Regenerative peripheral nerve interface
Paul S. Cederna, Milan, MI (US); Melanie G. Urbanchek, Ann Arbor, MI (US); and David C. Martin, Lincoln University, PA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US); and UNIVERSITY OF DELAWARE, Newark, DE (US)
Appl. No. 13/979,507
Filed by Paul S. Cederna, Milan, MI (US); Melanie G. Urbanchek, Ann Arbor, MI (US); and David C. Martin, Lincoln University, PA (US)
PCT Filed Jan. 13, 2012, PCT No. PCT/US2012/021311
§ 371(c)(1), (2), (4) Date Sep. 23, 2013,
PCT Pub. No. WO2012/097297, PCT Pub. Date Jul. 19, 2012.
Claims priority of provisional application 61/432,787, filed on Jan. 14, 2011.
Prior Publication US 2014/0005763 A1, Jan. 2, 2014
Int. Cl. A61N 1/00 (2006.01); A61N 1/05 (2006.01); A61F 2/72 (2006.01); A61L 27/34 (2006.01); A61F 2/08 (2006.01)
CPC A61N 1/0551 (2013.01) [A61F 2/0811 (2013.01); A61F 2/72 (2013.01); A61L 27/34 (2013.01); A61L 2430/32 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A regenerative peripheral nerve interface (RPNI) for a subject comprising:
an insulating substrate and at least one metallic electrode disposed on or in the insulating substrate, so that the insulating substrate and the at least one metallic electrode define a thin-film array;
a layer of decellularized biotic material comprising decellularized small intestinal submucosa (SIS); and
at least one conductive polymer.