US 9,808,560 B2
Biodegradable, non-thrombogenic elastomeric polyurethanes
Yi Hong, Irving, TX (US); William R Wagner, Gibsonia, PA (US); and Sang-Ho Ye, Pittsburgh, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed on Feb. 28, 2014, as Appl. No. 14/194,188.
Claims priority of provisional application 61/771,484, filed on Mar. 1, 2013.
Prior Publication US 2014/0248232 A1, Sep. 4, 2014
Int. Cl. A61K 31/74 (2006.01); A61L 33/06 (2006.01); A61L 27/18 (2006.01); A61L 27/58 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01)
CPC A61L 33/068 (2013.01) [A61L 27/18 (2013.01); A61L 27/58 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61L 33/064 (2013.01); A61L 2300/402 (2013.01); A61L 2300/404 (2013.01); A61L 2300/41 (2013.01); A61L 2300/416 (2013.01)] 29 Claims
 
1. A method of forming an implantable article, comprising: providing a biodegradable polymer comprising anti-thrombogenic zwitterionic groups at least one of within a backbone of the biodegradable polymer or pendant upon the backbone of the biodegradable polymer, biodegradable groups in the backbone of the biodegradable polymer and a plurality of functional groups reactive with reactive functional groups on a surface of the implantable article; and reacting at least a portion of the plurality of functional groups with the reactive functional groups on the surface of the implantable article to covalently bond the biodegradable polymer to the implantable article.