US 9,808,557 B2
Tubular silk compositions and methods of use thereof
Michael L. Lovett, Medford, MA (US); Xianyan Wang, Acton, MA (US); Christopher M. Cannizzaro, Washington, DC (US); Gordana Vunjak-Novakovic, New York, NY (US); and David L. Kaplan, Concord, MA (US)
Assigned to Trustees of Tufts College, Medford, MA (US); The Trustees of Columbia University in the City of New York, New York, NY (US); and Massachussets Institute of Technology, Cambridge, MA (US)
Appl. No. 12/672,521
Filed by Michael L. Lovett, Medford, MA (US); Xianyan Wang, Acton, MA (US); Christopher M. Cannizzaro, Washington, DC (US); Gordana Vunjak-Novakovic, New York, NY (US); and David L. Kaplan, Concord, MA (US)
PCT Filed Aug. 11, 2008, PCT No. PCT/US2008/072742
§ 371(c)(1), (2), (4) Date Feb. 2, 2012,
PCT Pub. No. WO2009/023615, PCT Pub. Date Feb. 19, 2009.
Claims priority of provisional application 60/995,091, filed on Aug. 10, 2007.
Prior Publication US 2012/0123519 A1, May 17, 2012
Int. Cl. A61F 2/06 (2013.01); A61L 27/36 (2006.01); A61L 27/22 (2006.01); A61F 2/08 (2006.01); A61L 27/26 (2006.01); A61F 2/07 (2013.01); A61F 2/82 (2013.01)
CPC A61L 27/227 (2013.01) [A61F 2/08 (2013.01); A61L 27/26 (2013.01); A61F 2/07 (2013.01); A61F 2/82 (2013.01); A61L 27/3604 (2013.01); D10B 2211/22 (2013.01); Y10T 428/13 (2015.01)] 23 Claims
 
1. A tubular composition in which a silk fibroin material forms a wall that defines an inner lumen having a diameter of less than 6 mm, and has a structure, including pore size, wherein the tubular composition achieves a burst strength of at least 1680 mm Hg, and wherein said wall has an apparent permeability coefficient of 7.3×10−4+/−1.5×10−4 cm/s or lower.