US 9,808,556 B2
Biocompatible and biodegradable elastomer
Shan-hui Hsu, Taipei (TW); and Kun-Che Hung, Taipei (TW)
Assigned to National Taiwan University, Taipei (TW)
Filed by National Taiwan University, Taipei (TW)
Filed on Jun. 28, 2016, as Appl. No. 15/195,578.
Application 15/195,578 is a continuation in part of application No. 14/145,393, filed on Dec. 31, 2013.
Claims priority of application No. 102100076 A (TW), filed on Jan. 2, 2013.
Prior Publication US 2016/0303279 A1, Oct. 20, 2016
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/18 (2006.01); A61L 27/52 (2006.01); A61F 2/06 (2013.01); A61L 27/58 (2006.01); C08G 18/40 (2006.01); C08G 18/42 (2006.01); C08G 18/75 (2006.01); A61L 27/56 (2006.01)
CPC A61L 27/18 (2013.01) [A61L 27/52 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); C08G 18/4018 (2013.01); C08G 18/4202 (2013.01); C08G 18/755 (2013.01); A61F 2210/0004 (2013.01); C08G 2230/00 (2013.01)] 14 Claims
 
1. A biocompatible and biodegradable elastomer, comprising: a main chain of polyurethane comprising a hard segment and a soft segment, the hard segment is formed by reaction of diisocyanate, 2,2-bis(hydroxymethyl)propionic acid and a chain extender, and the soft segment is a biodegradable oligomer diol, wherein the biodegradable oligomer diol is a combination consisting of 40˜96 mol % polycaprolactone diol and 4˜60 mol % polylactic acid diol, a combination consisting of 94˜96 mol % polycaprolactone diol and 4˜6 mol % poly(ethylene glycol) diol or a combination consisting of 78˜84 mol % polycaprolactone diol, 12˜18 mol % poly-DL-lactic acid diol and 4˜6 mol % poly(ethylene glycol) diol;
wherein the polylactic acid diol has a molecular weight of 1040-2520 g/mol and poly(ethylene glycol) diol has a molecular weight of 1450-2400 g/mol; and
wherein the molar ratio of diisocyanate:soft segment:2,2-bis(hydroxymethyl)propionic acid:chain extender is 3-4:1:1-2:1.52.