US 9,808,555 B2
Biomineralization promoting materials and methods of forming same
Esmaiel Jabbari, Columbia, SC (US)
Assigned to University of South Carolina, Columbia, SC (US)
Filed by University of South Carolina, Columbia, SC (US)
Filed on Mar. 9, 2016, as Appl. No. 15/65,084.
Application 15/065,084 is a division of application No. 14/260,442, filed on Apr. 24, 2014, granted, now 9,314,549.
Claims priority of provisional application 61/854,441, filed on Apr. 24, 2013.
Claims priority of provisional application 61/854,437, filed on Apr. 24, 2013.
Prior Publication US 2016/0250379 A1, Sep. 1, 2016
Int. Cl. A61K 9/70 (2006.01); A61L 27/12 (2006.01); A61L 27/22 (2006.01); A61L 27/54 (2006.01); A61K 9/00 (2006.01); A61L 27/58 (2006.01); A61L 27/50 (2006.01); A61L 27/56 (2006.01); A61F 2/28 (2006.01); A61L 27/18 (2006.01); B29C 47/00 (2006.01); B29C 51/00 (2006.01); B29C 51/02 (2006.01); B29C 65/02 (2006.01); D01D 5/00 (2006.01); B29K 67/00 (2006.01); B29K 105/00 (2006.01); B29L 31/00 (2006.01)
CPC A61L 27/12 (2013.01) [A61F 2/28 (2013.01); A61K 9/0024 (2013.01); A61L 27/18 (2013.01); A61L 27/227 (2013.01); A61L 27/50 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); B29C 47/0004 (2013.01); B29C 47/0054 (2013.01); B29C 47/0076 (2013.01); B29C 51/004 (2013.01); B29C 51/02 (2013.01); B29C 65/02 (2013.01); D01D 5/003 (2013.01); A61L 2300/112 (2013.01); A61L 2300/412 (2013.01); A61L 2400/12 (2013.01); A61L 2430/02 (2013.01); B29K 2067/043 (2013.01); B29K 2067/046 (2013.01); B29K 2105/0073 (2013.01); B29K 2105/0088 (2013.01); B29K 2105/256 (2013.01); B29K 2995/0056 (2013.01); B29L 2031/7532 (2013.01); D01D 5/0076 (2013.01); D10B 2331/041 (2013.01); D10B 2401/00 (2013.01); D10B 2509/00 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A method for forming a bone tissue biomimetic material comprising:
electrospinning a first solution to form a first fibrous sheet including nanofibers, the first solution including a biocompatible polymer conjugated to a peptide, the peptide comprising multiple acidic amino acid residues; and
incubating the first fibrous sheet in a simulated body fluid that includes calcium ions, phosphate ions, and an organic acid, calcium phosphate crystals nucleating on the nanofibers of the first fibrous sheet during the incubation.