US 9,808,548 B2
Regeneration of antimicrobial coatings containing metal derivatives upon exposure to vapor-phase hydrogen peroxide
William Toreki, Gainesville, FL (US); Rustom Sam Kanga, Kennesaw, GA (US); Bernard Christopher Crampsie, Auckland (NZ); and Brendan Barry Wynn, Auckland (NZ)
Assigned to QUICK-MED TECHNOLOGIES, INC., Gainesville, FL (US)
Filed by Quick-Med Technologies, Inc., Gainesville, FL (US)
Filed on Jun. 17, 2015, as Appl. No. 14/741,606.
Claims priority of provisional application 62/014,036, filed on Jun. 18, 2014.
Prior Publication US 2015/0366214 A1, Dec. 24, 2015
Int. Cl. A01N 25/10 (2006.01); A01N 25/34 (2006.01); A61L 2/20 (2006.01); B05D 3/04 (2006.01); B05D 5/00 (2006.01); A01N 59/16 (2006.01); A61L 2/232 (2006.01); A01N 59/00 (2006.01); A61L 2/238 (2006.01)
CPC A61L 2/208 (2013.01) [A01N 25/10 (2013.01); A01N 25/34 (2013.01); A01N 59/00 (2013.01); A01N 59/16 (2013.01); A61L 2/202 (2013.01); A61L 2/232 (2013.01); A61L 2/238 (2013.01); B05D 3/0446 (2013.01); B05D 3/0453 (2013.01); B05D 5/00 (2013.01); A61L 2300/102 (2013.01); A61L 2300/11 (2013.01); B05D 2201/02 (2013.01)] 14 Claims
 
1. A method of enhancing and regenerating durable antimicrobial activity of the surface of an article, wherein said method comprises the steps in sequence of:
a. providing, on the surface of an article on which durable antimicrobial activity is desired, a polymer doped with a metal derivative,
b. exposing the polymer doped with a metal derivative to a source of vapor-phase hydrogen peroxide for a time sufficient to permit an antimicrobially-enhancing amount of hydrogen peroxide to be sequestered thereon, and thereafter,
c. removing the source of vapor-phase hydrogen peroxide,
wherein said metal derivative comprises 1% to 50% (w/w) of the weight of the doped polymer, wherein said metal derivative is a hydroxide, an oxide, or a peroxide of a metal selected from the group consisting of zinc, magnesium, titanium, and zirconium,
wherein the water absorbency of said polymer is between 0.5% and 20% (w/w),
whereby said antimicrobial activity, when tested using ASTM Standard Method E2180-07(2012) at least 24 hours after said removal of the source of vapor-phase hydrogen peroxide, provides at least a 3-log reduction of viable Escherichia coli bacteria greater than that of a corresponding surface of said polymer doped with said metal derivative which has not been exposed to vapor phase hydrogen peroxide.