US 9,808,543 B2
Iron garnet nanoparticles for cancer radiotherapy and chemotherapy
Anthony J. Di Pasqua, Fort Worth, TX (US); Kenneth J. Balkus, Jr., The Colony, TX (US); Imalka S. Munaweera, Richardson, TX (US); and Yi Shi, Fort Worth, TX (US)
Assigned to UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH, Fort Worth, TX (US); and THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed by UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH, Fort Worth, TX (US); and THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed on Jan. 20, 2015, as Appl. No. 14/600,738.
Claims priority of provisional application 61/929,394, filed on Jan. 20, 2014.
Prior Publication US 2015/0202337 A1, Jul. 23, 2015
Int. Cl. A61K 51/12 (2006.01); A61K 33/24 (2006.01); A61K 31/555 (2006.01); A61K 45/06 (2006.01); A61K 33/00 (2006.01); A61K 33/22 (2006.01); A61K 33/26 (2006.01); A61K 33/38 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/27 (2006.01); A61K 38/30 (2006.01); A61N 5/10 (2006.01)
CPC A61K 51/1244 (2013.01) [A61K 31/555 (2013.01); A61K 33/00 (2013.01); A61K 33/22 (2013.01); A61K 33/24 (2013.01); A61K 33/26 (2013.01); A61K 33/38 (2013.01); A61K 38/18 (2013.01); A61K 38/193 (2013.01); A61K 38/27 (2013.01); A61K 38/30 (2013.01); A61K 45/06 (2013.01); A61K 51/1275 (2013.01); A61N 5/1029 (2013.01); A61N 5/1007 (2013.01); A61N 2005/1021 (2013.01)] 12 Claims
 
1. A film, electrospun fabric or bandage comprising a polymer-embedded iron garnet nanoparticle or iron garnet particle comprising one, or any combination of, activatable nuclide selected from lanthanum-139, praseodymium-141, samarium-152, dysprosium-164, holmium-165, rhenium-185 and/or rhenium-187 and, optionally, a radiosensitizer, said film, electrospun fabric or bandage emitting relatively uniform radiation across the surface area of said film, electrospun fabric or bandage after activation.