US 9,808,540 B2
Contrast agent for nuclear magnetic resonance imaging comprising melanin nanoparticles stably dispersed in water
Jin Kyu Lee, Seoul (KR); Kuk Youn Ju, Seoul (KR); and Jung Hee Lee, Seoul (KR)
Assigned to Melanis Co., Ltd., Seoul (KR)
Appl. No. 14/391,217
Filed by SNU R&DB FOUNDATION, Seoul (KR); and RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, Gyeonggi-do (KR)
PCT Filed Apr. 9, 2013, PCT No. PCT/KR2013/002959
§ 371(c)(1), (2) Date Feb. 2, 2015,
PCT Pub. No. WO2013/154329, PCT Pub. Date Oct. 17, 2013.
Claims priority of application No. 10-2012-0037004 (KR), filed on Apr. 9, 2012.
Prior Publication US 2015/0139914 A1, May 21, 2015
Int. Cl. A61K 49/18 (2006.01); A61K 49/10 (2006.01); A61K 49/16 (2006.01); A61K 49/12 (2006.01)
CPC A61K 49/1818 (2013.01) [A61K 49/103 (2013.01); A61K 49/106 (2013.01); A61K 49/126 (2013.01); A61K 49/16 (2013.01); A61K 49/186 (2013.01)] 33 Claims
 
1. A contrast agent for nuclear magnetic resonance imaging, comprising:
melanin nanoparticles having stable dispersibility in water; and
paramagnetic metal ions which are coordinated on the surface of the melanin nanoparticles.