US 9,808,519 B2
Composition for inducing proliferation or accumulation of regulatory T cells
Kenya Honda, Tokyo (JP); Koji Atarashi, Tokyo (JP); Kikuji Itoh, Tokyo (JP); and Takeshi Tanoue, Tokyo (JP)
Assigned to The University of Tokyo, Tokyo (JP)
Filed by The University of Tokyo, Tokyo (JP)
Filed on May 9, 2017, as Appl. No. 15/590,257.
Application 15/590,257 is a continuation of application No. 15/216,015, filed on Jul. 21, 2016.
Application 15/216,015 is a continuation of application No. 14/492,850, filed on Sep. 22, 2014, granted, now 9,433,652.
Application 14/492,850 is a continuation of application No. 13/701,467, abandoned, previously published as PCT/JP2011/063302, filed on Jun. 3, 2011.
Claims priority of application No. 2010-129134 (JP), filed on Jun. 4, 2010; and application No. PCT/JP2010/071746 (WO), filed on Dec. 3, 2010.
Prior Publication US 2017/0246283 A1, Aug. 31, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/08 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/08 (2013.01) [A61K 2039/52 (2013.01); A61K 2039/542 (2013.01); A61K 2039/57 (2013.01)] 28 Claims
1. A pharmaceutical composition comprising a spore-forming fraction of human fecal matter formulated for delivery to the intestine, wherein the composition induces proliferation and/or accumulation of regulatory T cells, wherein the spore-forming fraction is resistant to chloroform, and wherein the composition is formulated for oral administration.