US 9,808,514 B2
Method of using salmon thrombin to alleviate central nervous system-mediated pain
Beth A. Winkelstein, Freeport, ME (US); Paul A. Janmey, Freeport, ME (US); and Evelyn S. Sawyer, Freeport, ME (US)
Assigned to Sea Run Holdings, Inc., Freeport, ME (US)
Filed by Beth A. Winkelstein, Freeport, ME (US); Paul A. Janmey, Freeport, ME (US); and Evelyn S. Sawyer, Freeport, ME (US)
Filed on Oct. 20, 2009, as Appl. No. 12/582,040.
Claims priority of provisional application 61/111,828, filed on Nov. 6, 2008.
Prior Publication US 2010/0111926 A1, May 6, 2010
Int. Cl. A61K 38/48 (2006.01); C12N 9/74 (2006.01)
CPC A61K 38/4833 (2013.01) 22 Claims
 
1. A method of alleviating central nervous system-mediated pain, comprising applying salmon thrombin at a neural injury site, thereby diminishing a degree of nerve sensitivity to pain experienced at the site, wherein diminishing a degree of nerve sensitivity to pain experienced at the site includes reducing an inflammatory response at the site.