US 9,808,511 B2
Method for treating alopecia with B-type natriuretic peptide
Kyoko Endo, Sendai (JP)
Assigned to IGISU Co., Ltd., Tokyo (JP); and Yori Endo, Sendai-shi (JP)
Filed by IGISU Co., Ltd., Tokyo (JP); Yori Endo, Sendai-shi, Miyagi (JP); and Kyoko Endo, Sendai-shi, Miyagi (JP)
Filed on Sep. 20, 2016, as Appl. No. 15/270,350.
Application 15/270,350 is a continuation of application No. 14/254,938, filed on Apr. 17, 2014, granted, now 9,480,728.
Application 14/254,938 is a continuation of application No. 13/355,484, filed on Jan. 21, 2012, abandoned.
Claims priority of provisional application 61/437,032, filed on Jan. 28, 2011.
Claims priority of application No. 2011-11437 (JP), filed on Jan. 21, 2011.
Prior Publication US 2017/0065680 A1, Mar. 9, 2017
Int. Cl. A61K 38/22 (2006.01); A61K 8/64 (2006.01); A61K 9/00 (2006.01); A61Q 7/00 (2006.01); A61K 31/14 (2006.01); A61K 31/506 (2006.01); A61K 31/573 (2006.01); A61K 31/7036 (2006.01); A61K 45/06 (2006.01)
CPC A61K 38/22 (2013.01) [A61K 8/64 (2013.01); A61K 9/0014 (2013.01); A61K 31/14 (2013.01); A61K 31/506 (2013.01); A61K 31/573 (2013.01); A61K 31/7036 (2013.01); A61K 45/06 (2013.01); A61Q 7/00 (2013.01)] 15 Claims
 
1. A method of treating alopecia, the method comprising:
externally applying a composition that comprises an effective amount of B-type natriuretic peptide (BNP) to a required site of skin of a subject in need of such treatment,
wherein the BNP comprises an amino acid sequence selected from the group comprising the human amino acid sequence of BNP-26, BNP-32 or BNP-45, and
wherein the alopecia is one or more selected from the group consisting of alopecia areata, androgenetic alopecia, seborrheic alopecia, alopecia pityroides, female pattern alopecia, postpartum alopecia, senile alopecia, cancer chemotherapy drug-induced alopecia and alopecia due to radiation exposure.