US 9,808,508 B2
Methods for treating metabolic disorders using FGF
Johan W. Jonker, Gronigen (NL); Michael Downes, San Diego, CA (US); Ronald M. Evans, La Jolla, CA (US); and Jae Myoung Suh, San Diego, CA (US)
Assigned to Salk Institude for Biological Studies, La Jolla, CA (US)
Filed by Salk Institute for Biological Studies, La Jolla, CA (US)
Filed on Aug. 18, 2016, as Appl. No. 15/240,803.
Application 14/526,058 is a division of application No. 14/184,621, filed on Feb. 19, 2014, granted, now 8,906,854, issued on Dec. 9, 2014.
Application 14/184,621 is a division of application No. 13/641,451, abandoned, previously published as PCT/US2011/032848, filed on Apr. 18, 2011.
Application 15/240,803 is a continuation of application No. 14/731,705, filed on Jun. 5, 2015, granted, now 9,446,097.
Application 14/731,705 is a continuation of application No. 14/526,058, filed on Oct. 28, 2014, granted, now 9,072,708, issued on Jul. 7, 2015.
Claims priority of provisional application 61/325,255, filed on Apr. 16, 2010.
Claims priority of provisional application 61/325,253, filed on Apr. 16, 2010.
Claims priority of provisional application 61/325,261, filed on Apr. 16, 2010.
Prior Publication US 2016/0354440 A1, Dec. 8, 2016
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/18 (2006.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01); A61K 31/4439 (2006.01); A61K 47/48 (2006.01)
CPC A61K 38/1825 (2013.01) [A61K 9/0019 (2013.01); A61K 31/4439 (2013.01); A61K 45/06 (2013.01); A61K 47/4823 (2013.01); A61K 47/48215 (2013.01)] 25 Claims
 
1. A method for initiating or maintaining weight loss of a diabetic, hyperglycemic, and/or insulin resistant individual having a body mass index (BMI) of 25 or higher, comprising systemically administering an FGF-1 compound having at least 80% identity to human FGF-1 to the individual in an amount effective to initiate or maintain weight loss of the individual.