US 9,808,507 B2
Anti-c-Met/anti-Ang2 bispecific antibody
Seungja Oh, Seoul (KR); Kyung Ah Kim, Seongnam-si (KR); Bo Gyou Kim, Seoul (KR); Seung Hyun Lee, Suwon-si (KR); and Ji Min Lee, Seoul (KR)
Assigned to SAMSUNG ELECTRONICS CO., LTD., Suwon-si (KR)
Filed by Samsung Electronics Co., Ltd., Suwon-si, Gyeonggi-do (KR)
Filed on Aug. 25, 2015, as Appl. No. 14/835,376.
Claims priority of application No. 10-2014-0110868 (KR), filed on Aug. 25, 2014.
Prior Publication US 2016/0053025 A1, Feb. 25, 2016
Int. Cl. C07K 16/22 (2006.01); A61K 38/18 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01)
CPC A61K 38/18 (2013.01) [A61K 38/1891 (2013.01); C07K 16/22 (2013.01); C07K 16/2863 (2013.01); A61K 2039/507 (2013.01); A61K 2039/545 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01)] 13 Claims
 
1. An anti-c-Met/anti-Ang2 bispecific antibody comprising (a) an anti-c-Met antibody or antigen-binding fragment thereof and (b) an anti-Ang2 antibody or antigen-binding fragment thereof, wherein
the anti-c-Met antibody or antigen-binding fragment thereof comprises (i) a heavy chain variable region comprising (a) a CDR-H1 comprising SEQ ID NO: 1, 22, 23, or 24, (b) a CDR-H2 comprising SEQ ID NO: 2, 25, or 26, and (c) a CDR-H3 comprising SEQ ID NO: 3, 27, 28, or 85, and (ii) a light chain variable region comprising (a) a CDR-L1 comprising an SEQ ID NO: 10, 29, 30, 31, 32, 33 or 106, (b) a CDR-L2 comprising SEQ ID NO: 11, 34, 35, or 36, and (c) a CDR-L3 comprising SEQ ID NO: 12, 13, 14, 15, 16, 37, 86, or 89;
and the anti-Ang-2 antibody or antigen-binding fragment thereof comprises:
(i) a heavy chain variable region comprising (a) a CDR-H1 comprising SEQ ID NO: 109, (b) a CDR-H2 comprising SEQ ID NO: 128, and (c) a CDR-H3 comprising SEQ ID NO: 111, and (ii) a light chain variable region comprising a CDR-L1 comprising SEQ ID NO: 129, a CDR-L2 comprising SEQ ID NO: 130, and a CDR-L3 comprising SEQ ID NO: 131.