US 9,808,503 B2
Allergen peptide fragments and use thereof for treatment of birch pollen allergies
Francois Spertini, Epalinges (CH); and Blaise Corthesy, Cugy (CH)
Assigned to ANERGIS S.A., Epalinges (CH)
Filed by ANERGIS S.A., Epalinges (CH)
Filed on Nov. 23, 2015, as Appl. No. 14/949,019.
Application 14/949,019 is a division of application No. 14/206,354, filed on Mar. 12, 2014, granted, now 9,193,773.
Application 14/206,354 is a division of application No. 13/284,383, filed on Oct. 28, 2011, granted, now 8,703,144.
Application 13/284,383 is a division of application No. 11/226,162, filed on Sep. 14, 2005, granted, now 8,075,897.
Application 11/226,162 is a continuation in part of application No. PCT/IB2004/001300, filed on Mar. 15, 2004.
Application PCT/IB2004/001300 is a continuation of application No. 10/799,514, filed on Mar. 12, 2004, granted, now 7,923,209.
Claims priority of provisional application 60/455,004, filed on Mar. 14, 2003.
Prior Publication US 2016/0095899 A1, Apr. 7, 2016
Int. Cl. A61K 38/16 (2006.01); A61K 39/35 (2006.01); C07K 14/415 (2006.01); C07K 14/435 (2006.01)
CPC A61K 38/168 (2013.01) [A61K 39/35 (2013.01); C07K 14/415 (2013.01); C07K 14/43531 (2013.01); C07K 14/43563 (2013.01); C07K 14/43572 (2013.01)] 1 Claim
 
1. A composition comprising a plurality of contiguous overlapping peptide fragments 30 to 73 amino acids in length which peptide fragments consist of peptides within SEQ ID NOs: 8 and 9 which together comprise the entire amino acid sequence of a birch pollen profilin allergen (SEQ ID NO: 10), wherein said fragments are capable of inducing a T cell response in patients hypersensitive to said allergen
wherein the reactivity of said peptides to IgE antibodies of subjects who are allergic to birch pollen profilin allergen is significantly reduced or eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen profilin allergen is retained.